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• W2124248825 endingPage "333" @default.
• W2124248825 startingPage "319" @default.
• W2124248825 abstract "Addition of brefeldin A (BFA) to mammalian cells rapidly results in the removal of coatomer from membranes and subsequent delivery of Golgi enzymes to the endoplasmic reticulum (ER). Microinjected anti-EAGE (intact IgG or Fab-fragments), antibodies against the “EAGE”-peptide of β-COP, inhibit BFA-induced redistribution of β-COP in vivo and block transfer of resident proteins of the Golgi complex to the ER; tubulo-vesicular clusters accumulate and Golgi membrane proteins concentrate in cytoplasmic patches containing β-COP. These patches are devoid of marker proteins of the ER, the intermediate compartment (IC), and do not contain KDEL receptor. Interestingly, relocation of KDEL receptor to the IC, where it colocalizes with ERGIC53 and ts-O45-G, is not inhibited under these conditions. While no stacked Golgi cisternae remain in these injected cells, reassembly of stacks of Golgi cisternae following BFA wash-out is inhibited to only ∼50%. Mono- or divalent anti-EAGE stabilize binding of coatomer to membranes in vitro, at least as efficiently as GTPγS. Taken together these results suggest that enhanced binding of coatomer to membranes completely inhibits the BFA-induced retrograde transport of Golgi resident proteins to the ER, probably by inhibiting fusion of Golgi with ER membranes, but does not interfere with the disassembly of the stacked Golgi cisternae and recycling of KDEL receptor to the IC. These results confirm our previous results suggesting that COPI is involved in anterograde membrane transport from the ER/IC to the Golgi complex (Pepperkok et al., 1993), and corroborate that COPI regulates retrograde membrane transport between the Golgi complex and ER in mammalian cells." @default.
• W2124248825 created "2016-06-24" @default.
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• W2124248825 creator A5017298007 @default.
• W2124248825 creator A5041893505 @default.
• W2124248825 creator A5071701842 @default.
• W2124248825 date "1997-04-21" @default.
• W2124248825 modified "2023-10-03" @default.
• W2124248825 title "Dissociation of Coatomer from Membranes Is Required for Brefeldin A–induced Transfer of Golgi Enzymes to the Endoplasmic Reticulum" @default.
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• W2124248825 doi "https://doi.org/10.1083/jcb.137.2.319" @default.
• W2124248825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2139784" @default.
• W2124248825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9128245" @default.
• W2124248825 hasPublicationYear "1997" @default.
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