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• W2124257586 abstract "Weight regain after Roux-en-Y gastric bypass (RYGB) is common. Endoscopic sclerotherapy is increasingly used to treat this weight regain.To report safety, outcomes, durability, and predictors of response to sclerotherapy in a large prospective cohort.Retrospective analysis of a prospective cohort study of patients with weight regain after RYGB.A total of 231 consecutive patients undergoing 575 sclerotherapy procedures between September 2008 and March 2011.Single or multiple sclerotherapy procedures to inject sodium morrhuate into the rim of the gastrojejunal anastomosis.We report weight loss, complications, and predictors of response. We also used Kaplan-Meier survival analysis and log-rank test to compare time to continuation of weight regain after sclerotherapy in patients undergoing a single versus multiple sclerotherapy procedures.At 6 and 12 months from the last sclerotherapy procedure, weight regain stabilized in 92% and 78% of the cohort, respectively. Those who underwent 2 or 3 sclerotherapy sessions had significantly higher rates of weight regain stabilization than those who underwent a single session (90% vs 60% at 12 months; P = .003). The average weight loss at 6 months from the last sclerotherapy session for the entire cohort was 10 lb (standard deviation 16), representing 18% of the weight regained after RYGB. A subset of 73 patients (32% of the cohort) had greater weight loss at 6 months (26 lb, standard deviation 12), representing 61% of the weight regained. Predictors of a favorable outcome included greater weight regain and the number of sclerotherapy procedures. Bleeding was reported in 2.4% of procedures and transient diastolic blood pressure increases in 15%, without adverse health outcomes. No GI perforations were reported.Endoscopic sclerotherapy appears to be a safe and effective tool for the management of weight regain after RYGB." @default.
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• W2124257586 date "2012-08-01" @default.
• W2124257586 modified "2023-09-25" @default.
• W2124257586 title "Endoscopic sclerotherapy for the treatment of weight regain after Roux-en-Y gastric bypass: outcomes, complications, and predictors of response in 575 procedures" @default.
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• W2124257586 doi "https://doi.org/10.1016/j.gie.2012.03.1407" @default.
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