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- W2124289321 abstract "Multiple myeloma is associated with the development of a devastating bone disease mediated by increased osteoclastic activity. The ligand for receptor activator of nuclear factor-κB (RANKL) plays a critical role in normal osteoclast biology and is abnormally regulated in myeloma. Targeting this system with recombinant decoy receptor, osteoprotegerin, or soluble forms of the receptor activator of nuclear factor-κB is able to prevent myeloma bone disease in pre-clinical models. Intriguingly, inhibiting osteoclast formation and bone resorption, and altering the bone marrow microenvironment, results in an indirect anti-myeloma effect." @default.
- W2124289321 created "2016-06-24" @default.
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- W2124289321 date "2004-08-01" @default.
- W2124289321 modified "2023-09-25" @default.
- W2124289321 title "Evidence of a role for RANKL in the development of myeloma bone disease" @default.
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- W2124289321 doi "https://doi.org/10.1016/j.coph.2004.03.011" @default.
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