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• W2124289565 endingPage "572" @default.
• W2124289565 startingPage "567" @default.
• W2124289565 abstract "Summary. The inhibitory capacity of plasma samples from 24 patients with severe haemophilia A and high‐responding inhibitors were evaluated in a concentrate‐based assay using two plasma‐derived (Haemate and Monoclate‐P) and three recombinant (Helixate, Recombinate and ReFacto) factor VIII concentrates and correlated with the corresponding epitope profile. In most, but not all, inhibitor plasmas with a relatively low reactivity against the von Willebrand‐containing product Haemate, the main epitopes were located in the FVIII light chain. The reactivities within the group of recombinant products varied in that the reactivity against the B‐domain deleted ReFacto was in general higher than that against Recombinate and Helixate. This difference did not correlate with any particular epitope profile and indicates that the B‐domain, type of formulation and/or purification procedures may have an impact on the inhibitor reactivity in vitro . The ratio between the inhibitor titres in the concentrate‐based assay and the Bethesda assay was dependent on the inhibitor plasma and concentrate used. Taken together, our results show that the reactivity of inhibitor plasmas varies considerably between different FVIII concentrates and that it does not fully correlate with the epitope profile. Potential clinical implications of the observed differences in inhibitor reactivity are discussed." @default.
• W2124289565 created "2016-06-24" @default.
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• W2124289565 date "2003-09-01" @default.
• W2124289565 modified "2023-10-16" @default.
• W2124289565 title "Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates <i>in vitro</i>" @default.
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• W2124289565 doi "https://doi.org/10.1046/j.1365-2516.2003.00802.x" @default.
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