Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124302607> ?p ?o ?g. }
- W2124302607 endingPage "1203" @default.
- W2124302607 startingPage "1189" @default.
- W2124302607 abstract "SUMMARY A study has been carried out to determine the activity of genistein against adult liver fluke, Fasciola hepatica . Flukes were incubated in vitro in genistein at a concentration of 0·27 mg/ml (=1 m m ). They ceased to move after 3 h, at which point the experiment was terminated and the specimens prepared for examination by scanning and transmission electron microscopy. Surface changes to the flukes comprised swelling and blebbing, especially in the posterior region of the flukes, and there was particular disruption to the spines, accompanied by some spine loss. Fine structural changes to the tegumental syncytium indicated an accelerated release of secretory bodies at the surface, but a reduction in their production within the cell bodies. Autophagic activity was evident in the tegumental cells, a phenomenon that was also observed in the gastrodermal cells. Disruption to the testis and vitelline follicles was severe, with an apparent block in the normal developmental sequence of the spermatogenic and vitelline cells, respectively. Shell protein production by the vitelline cells was also disrupted. In separate experiments, somatic muscle strips were exposed to concentrations of genistein ranging from 1 μ m to 1 m m . There were statistically significant increases in the frequency and/or amplitude of muscle contractions at concentrations of 10 μ m , 100 μ m and 1 m m . The results suggest that genistein is capable of causing severe morphological and neuromuscular disruption to adult flukes in vitro over a short time-span." @default.
- W2124302607 created "2016-06-24" @default.
- W2124302607 creator A5025940136 @default.
- W2124302607 creator A5026787638 @default.
- W2124302607 creator A5040149448 @default.
- W2124302607 creator A5042133470 @default.
- W2124302607 creator A5056281445 @default.
- W2124302607 date "2008-09-01" @default.
- W2124302607 modified "2023-09-27" @default.
- W2124302607 title "Physiological and morphological effects of genistein against the liver fluke,<i>Fasciola hepatica</i>" @default.
- W2124302607 cites W1547708503 @default.
- W2124302607 cites W1588362455 @default.
- W2124302607 cites W1656644300 @default.
- W2124302607 cites W1964503694 @default.
- W2124302607 cites W1965897933 @default.
- W2124302607 cites W1968653759 @default.
- W2124302607 cites W1968851564 @default.
- W2124302607 cites W1972778830 @default.
- W2124302607 cites W1972823894 @default.
- W2124302607 cites W1982743860 @default.
- W2124302607 cites W1984164274 @default.
- W2124302607 cites W1985546141 @default.
- W2124302607 cites W1989371763 @default.
- W2124302607 cites W1990879803 @default.
- W2124302607 cites W1994207727 @default.
- W2124302607 cites W2000705826 @default.
- W2124302607 cites W2001252659 @default.
- W2124302607 cites W2009478675 @default.
- W2124302607 cites W2011527577 @default.
- W2124302607 cites W2014878290 @default.
- W2124302607 cites W2030181833 @default.
- W2124302607 cites W2031438796 @default.
- W2124302607 cites W2034758586 @default.
- W2124302607 cites W2036140633 @default.
- W2124302607 cites W2036243256 @default.
- W2124302607 cites W2041603571 @default.
- W2124302607 cites W2047630475 @default.
- W2124302607 cites W2052843521 @default.
- W2124302607 cites W2053642730 @default.
- W2124302607 cites W2061412275 @default.
- W2124302607 cites W2061703004 @default.
- W2124302607 cites W2063597830 @default.
- W2124302607 cites W2065449717 @default.
- W2124302607 cites W2068906717 @default.
- W2124302607 cites W2068918741 @default.
- W2124302607 cites W2070986809 @default.
- W2124302607 cites W2072557051 @default.
- W2124302607 cites W2073015741 @default.
- W2124302607 cites W2073476932 @default.
- W2124302607 cites W2074669780 @default.
- W2124302607 cites W2080615903 @default.
- W2124302607 cites W2081907039 @default.
- W2124302607 cites W2085346770 @default.
- W2124302607 cites W2085468181 @default.
- W2124302607 cites W2085843951 @default.
- W2124302607 cites W2089522498 @default.
- W2124302607 cites W2092085753 @default.
- W2124302607 cites W2092160057 @default.
- W2124302607 cites W2092788370 @default.
- W2124302607 cites W2096173641 @default.
- W2124302607 cites W2098875580 @default.
- W2124302607 cites W2109692484 @default.
- W2124302607 cites W2124924913 @default.
- W2124302607 cites W2129719828 @default.
- W2124302607 cites W2134575926 @default.
- W2124302607 cites W2136202745 @default.
- W2124302607 cites W2137591194 @default.
- W2124302607 cites W2141474275 @default.
- W2124302607 cites W2147995249 @default.
- W2124302607 cites W2148715064 @default.
- W2124302607 cites W2161350974 @default.
- W2124302607 cites W2162685760 @default.
- W2124302607 cites W2165642682 @default.
- W2124302607 cites W2169313073 @default.
- W2124302607 cites W2324254601 @default.
- W2124302607 cites W2911273765 @default.
- W2124302607 cites W30888072 @default.
- W2124302607 doi "https://doi.org/10.1017/s0031182008004630" @default.
- W2124302607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18771609" @default.
- W2124302607 hasPublicationYear "2008" @default.
- W2124302607 type Work @default.
- W2124302607 sameAs 2124302607 @default.
- W2124302607 citedByCount "23" @default.
- W2124302607 countsByYear W21243026072012 @default.
- W2124302607 countsByYear W21243026072014 @default.
- W2124302607 countsByYear W21243026072015 @default.
- W2124302607 countsByYear W21243026072016 @default.
- W2124302607 countsByYear W21243026072017 @default.
- W2124302607 countsByYear W21243026072018 @default.
- W2124302607 countsByYear W21243026072019 @default.
- W2124302607 countsByYear W21243026072020 @default.
- W2124302607 countsByYear W21243026072021 @default.
- W2124302607 countsByYear W21243026072023 @default.
- W2124302607 crossrefType "journal-article" @default.
- W2124302607 hasAuthorship W2124302607A5025940136 @default.
- W2124302607 hasAuthorship W2124302607A5026787638 @default.
- W2124302607 hasAuthorship W2124302607A5040149448 @default.
- W2124302607 hasAuthorship W2124302607A5042133470 @default.