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• W2124305814 endingPage "7669" @default.
• W2124305814 startingPage "7666" @default.
• W2124305814 abstract "Interstrand DNA-DNA cross-links are highly toxic to cells because these lesions block the extraction of information from the genetic material. The pathways by which cells repair cross-links are important, but not well understood. The preparation of chemically well-defined cross-linked DNA substrates represents a significant challenge in the study of cross-link repair. Here a simple method is reported that employs post-synthetic modifications of commercially available 2'-deoxyoligonucleotides to install a single cross-link in high yield at a specified location within a DNA duplex. The cross-linking process exploits the formation of a hydrazone between a non-natural N(4) -amino-2'-deoxycytidine nucleobase and the aldehyde residue of an abasic site in duplex DNA. The resulting cross-link is stable under physiological conditions, but can be readily dissociated and re-formed through heating-cooling cycles." @default.
• W2124305814 created "2016-06-24" @default.
• W2124305814 creator A5013602438 @default.
• W2124305814 creator A5070643439 @default.
• W2124305814 date "2015-05-12" @default.
• W2124305814 modified "2023-10-18" @default.
• W2124305814 title "A Simple, High-Yield Synthesis of DNA Duplexes Containing a Covalent, Thermally Cleavable Interstrand Cross-Link at a Defined Location" @default.
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• W2124305814 doi "https://doi.org/10.1002/anie.201502566" @default.
• W2124305814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4532324" @default.
• W2124305814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25967397" @default.
• W2124305814 hasPublicationYear "2015" @default.
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