Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124307574> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2124307574 endingPage "432" @default.
- W2124307574 startingPage "427" @default.
- W2124307574 abstract "Background: Patients with left-ventricular dysfunction have an increased risk of developing heart failure after coronary artery bypass graft (CABG) surgery. Therapies to maintain cardiac output in such patients warrant investigation. Nesiritide is unique among intravenous medications used to manage heart failure. It mediates natriuresis and vasodilation and suppresses the renin–angiotensin'aldosterone axis. Nesiritide may attenuate the body's neurohormonal response to myocardial stretch after CABG and provide clinical benefit in the immediate postoperative period. Objective: To determine whether perioperative infusion of nesiritide improves clinical outcomes compared with milrinone therapy. Methods: A prospective, open-label, randomized controlled trial was conducted in 40 consecutive hemodynamically stable patients with ejection fractions 35% or less undergoing CABG surgery. Patients were randomized to receive either an intraoperative bolus of nesiritide or milrinone followed by a 24 hour infusion of each agent. Length of postoperative intensive care unit stay was the primary outcome variable evaluated. Incidence of postoperative heart failure, 30 day readmission rates, mortality, and other clinical parameters were also compared. Results: Patients receiving nesiritide had a mean ± SD postoperative intensive care unit stay of 50.6 ± 46.8 hours compared with 44.1 ± 23.5 hours in those receiving milrinone (p = 0.578). Incidence of postoperative heart failure was also not significantly different between the drugs (p = 0.259). Thirty day follow-up confirmed no difference in hospital readmission rates between nesiritide and milrinone (p = 0.661). No differences in mortality were observed during hospitalization or 30 days of follow-up. Conclusions: Nesiritide does not decrease postoperative intensive care unit stay or other clinical parameters compared with milrinone in high-risk patients with hemodynamically stable left-ventricular function undergoing CABG surgery." @default.
- W2124307574 created "2016-06-24" @default.
- W2124307574 creator A5025475321 @default.
- W2124307574 creator A5025723459 @default.
- W2124307574 creator A5070941167 @default.
- W2124307574 creator A5082550375 @default.
- W2124307574 date "2007-03-01" @default.
- W2124307574 modified "2023-09-27" @default.
- W2124307574 title "Perioperative Nesiritide Versus Milrinone in High-Risk Coronary Artery Bypass Graft Patients" @default.
- W2124307574 cites W1975971363 @default.
- W2124307574 cites W1977584503 @default.
- W2124307574 cites W1978066183 @default.
- W2124307574 cites W1988232724 @default.
- W2124307574 cites W1990992072 @default.
- W2124307574 cites W2048164304 @default.
- W2124307574 cites W2072892297 @default.
- W2124307574 cites W2098589322 @default.
- W2124307574 cites W2144397934 @default.
- W2124307574 cites W2319534362 @default.
- W2124307574 cites W55026472 @default.
- W2124307574 doi "https://doi.org/10.1345/aph.1h500" @default.
- W2124307574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17311834" @default.
- W2124307574 hasPublicationYear "2007" @default.
- W2124307574 type Work @default.
- W2124307574 sameAs 2124307574 @default.
- W2124307574 citedByCount "15" @default.
- W2124307574 countsByYear W21243075742012 @default.
- W2124307574 countsByYear W21243075742013 @default.
- W2124307574 countsByYear W21243075742015 @default.
- W2124307574 countsByYear W21243075742016 @default.
- W2124307574 countsByYear W21243075742018 @default.
- W2124307574 countsByYear W21243075742019 @default.
- W2124307574 crossrefType "journal-article" @default.
- W2124307574 hasAuthorship W2124307574A5025475321 @default.
- W2124307574 hasAuthorship W2124307574A5025723459 @default.
- W2124307574 hasAuthorship W2124307574A5070941167 @default.
- W2124307574 hasAuthorship W2124307574A5082550375 @default.
- W2124307574 hasConcept C126322002 @default.
- W2124307574 hasConcept C164705383 @default.
- W2124307574 hasConcept C2775901492 @default.
- W2124307574 hasConcept C2775915353 @default.
- W2124307574 hasConcept C2776376669 @default.
- W2124307574 hasConcept C2776645727 @default.
- W2124307574 hasConcept C2776820930 @default.
- W2124307574 hasConcept C2777386981 @default.
- W2124307574 hasConcept C2778198053 @default.
- W2124307574 hasConcept C2778789114 @default.
- W2124307574 hasConcept C31174226 @default.
- W2124307574 hasConcept C42219234 @default.
- W2124307574 hasConcept C71924100 @default.
- W2124307574 hasConcept C78085059 @default.
- W2124307574 hasConceptScore W2124307574C126322002 @default.
- W2124307574 hasConceptScore W2124307574C164705383 @default.
- W2124307574 hasConceptScore W2124307574C2775901492 @default.
- W2124307574 hasConceptScore W2124307574C2775915353 @default.
- W2124307574 hasConceptScore W2124307574C2776376669 @default.
- W2124307574 hasConceptScore W2124307574C2776645727 @default.
- W2124307574 hasConceptScore W2124307574C2776820930 @default.
- W2124307574 hasConceptScore W2124307574C2777386981 @default.
- W2124307574 hasConceptScore W2124307574C2778198053 @default.
- W2124307574 hasConceptScore W2124307574C2778789114 @default.
- W2124307574 hasConceptScore W2124307574C31174226 @default.
- W2124307574 hasConceptScore W2124307574C42219234 @default.
- W2124307574 hasConceptScore W2124307574C71924100 @default.
- W2124307574 hasConceptScore W2124307574C78085059 @default.
- W2124307574 hasIssue "3" @default.
- W2124307574 hasLocation W21243075741 @default.
- W2124307574 hasLocation W21243075742 @default.
- W2124307574 hasOpenAccess W2124307574 @default.
- W2124307574 hasPrimaryLocation W21243075741 @default.
- W2124307574 hasRelatedWork W1580905093 @default.
- W2124307574 hasRelatedWork W2043235688 @default.
- W2124307574 hasRelatedWork W2051712573 @default.
- W2124307574 hasRelatedWork W2077083067 @default.
- W2124307574 hasRelatedWork W2091139515 @default.
- W2124307574 hasRelatedWork W2355594703 @default.
- W2124307574 hasRelatedWork W2361407492 @default.
- W2124307574 hasRelatedWork W2538662566 @default.
- W2124307574 hasRelatedWork W3033076790 @default.
- W2124307574 hasRelatedWork W4382048704 @default.
- W2124307574 hasVolume "41" @default.
- W2124307574 isParatext "false" @default.
- W2124307574 isRetracted "false" @default.
- W2124307574 magId "2124307574" @default.
- W2124307574 workType "article" @default.