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• W2124328573 abstract "The immunoregulatory proteins C-C chemokines are potent chemoattractants of lymphocytes and monocytes, as well as activators and attractants of eosinophils and basophils. We have isolated a cDNA that encodes a seven transmembrane-spanning receptor, with homology to other chemoattractant receptors, that encodes a protein designated C-C CKR-1 that acts as a receptor for the C-C chemokines. Human and murine macrophage inflammatory protein 1α (MIP-1α), human macrophage inflammatory protein 1β (MIP-1β), human monocyte chemotactic protein 1 (MCP-1), and RANTES all bind to the C-C CKR-1 with varying affinities. Chemokine binding affinity does not predict how well the ligand will transmit a signal through the receptor: RANTES and human MIP-1α induce a similar intracellular calcium flux while binding with disparate affinities, while MCP-1 and human MIP-1β induce calcium mobilization only at high concentrations. Finally, C-C chemokines were shown to bind a C-C CKR-1-related gene product encoded by cytomegalovirus, suggesting a role for C-C chemokines in viral immunity." @default.
• W2124328573 created "2016-06-24" @default.
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• W2124328573 date "1993-02-01" @default.
• W2124328573 modified "2023-10-17" @default.
• W2124328573 title "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor" @default.
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• W2124328573 doi "https://doi.org/10.1016/0092-8674(93)90118-a" @default.
• W2124328573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7679328" @default.
• W2124328573 hasPublicationYear "1993" @default.
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