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• W2124332019 abstract "Duration and speed of propagation of the pulse are essential factors for stability of excitation waves. We explore the propagation of excitation waves resulting from periodic stimulation of an excitable cable to determine the minimal stable pulse duration in a rate-dependent modification of a Chernyak-Starobin-Cohen reaction-diffusion model. Various pacing rate dependent features of wave propagation were studied computationally and analytically. We demonstrated that the complexity of responses to stimulation and evolution of these responses from stable propagation to propagation block and alternans was determined by the proximity between the minimal level of the recovery variable and the critical excitation threshold for a stable solitary pulse. These results suggest that critical propagation of excitation waves determines conditions for transition to unstable rhythms in a way similar to unstable cardiac rhythms. Established conditions were suitably accurate regardless of rate dependent features and the magnitude of the slopes of restitution curves." @default.
• W2124332019 created "2016-06-24" @default.
• W2124332019 creator A5008988564 @default.
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• W2124332019 date "2009-07-09" @default.
• W2124332019 modified "2023-09-27" @default.
• W2124332019 title "Critical scale of propagation influences dynamics of waves in a model of excitable medium" @default.
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• W2124332019 doi "https://doi.org/10.1186/1753-4631-3-4" @default.
• W2124332019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2720971" @default.
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• W2124332019 hasPublicationYear "2009" @default.
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