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• W2124337098 abstract "We describe a novel method of adaptively controlling epileptic seizure-like events in hippocampal brain slices using electric fields. Extracellular neuronal activity is continuously recorded during field application through differential extracellular recording techniques, and the applied electric field strength is continuously updated using a computer-controlled proportional feedback algorithm. This approach appears capable of sustained amelioration of seizure events in this preparation when used with negative feedback. Seizures can be induced or enhanced by using fields of opposite polarity through positive feedback. In negative feedback mode, such findings may offer a novel technology for seizure control. In positive feedback mode, adaptively applied electric fields may offer a more physiological means of neural modulation for prosthetic purposes than previously possible." @default.
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• W2124337098 date "2001-01-15" @default.
• W2124337098 modified "2023-10-12" @default.
• W2124337098 title "Adaptive Electric Field Control of Epileptic Seizures" @default.
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• W2124337098 doi "https://doi.org/10.1523/jneurosci.21-02-00590.2001" @default.
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