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- W2124337753 abstract "Polycyclic aromatic hydrocarbons are ubiquitous environmental contaminants known to be carcinogenic as well as immunosuppressive Structure activity studies have demonstrated that modifications in the number of methylgroups of benzanthracenic compounds lead to major changes in their biological activities such as induction of tumors In the present study we investigated the immunosuppressive effects of three benzanthracene derivatives differing by number or position of methyl radicals 7 12 Dimethylbenz a anthracene 12 methylbenz a anthracene and 7 methylbenz a anthracene were tested for their ability to inhibit T cell proliferation For this purpose we employed an in vitro activation model uti lizing concanavalin A ConA or anti CD3 monoclonal antibody anti CD3 mAb to induce proliferation of murine T lymphocytes from B6C3F1 mice The three compounds inhibited splenocyte proliferation stimulated with anti CD3 mAb whereas DMBA and 12 MBA but not 7 MBA inhibited ConA induced lymphoproliferation Results concerning parameters involving interleukin 2 IL2 were correlated with those obtained for lympho proliferation IL 2 production and number of IL2 receptors IL 2R per cell were inhibited by the three molecules tested except for IL 2 production following ConA activation of cells treated with 7 MBA Only DMBA profoundly affected IL 2 responsiveness suggesting that this compound may inhibit both G0 to G1 and G1 to S transitions of the cell cycle Addition of exogenous cytokines such as IL 1 and IL 6 with IL 2 or IL 2 alone suggested that for the three compounds tested IL 1 and IL 6 production are not involved in benz a anthracene induced immunosuppression These results demonstrate that methyla tion at both 7 and 12 positions of the benzanthracene ring significantlyenhancesimmuno suppression In addition DMBA may act on signal transduction mediated by the T cell receptor TCR and the IL 2R while this is not the case for 7 MBA and 12 MBA" @default.
- W2124337753 created "2016-06-24" @default.
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- W2124337753 date "1996-11-01" @default.
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- W2124337753 title "EFFECTS OF METHYL SUBSTITUTIONS ON BENZ a ANTHRACENE DERIVATIVES INDUCED IMMUNOSUPPRESSION" @default.
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- W2124337753 doi "https://doi.org/10.1080/009841096160772" @default.
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