FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124342675> ?p ?o ?g. }

• W2124342675 endingPage "359" @default.
• W2124342675 startingPage "354" @default.
• W2124342675 abstract "Western equine encephalitis virus (WEEV) is a zoonotic alphavirus that circulates in western North America between passerine birds and mosquitoes, primarily Culex tarsalis. Since it was isolated in 1930, WEEV has caused tens of thousands of equine deaths in addition to thousands of human cases. In addition because WEEV is a virus of agricultural importance in addition to a public health threat, we developed two live-attenuated chimeric vaccine candidates that have been shown to be immunogenic and efficacious in mouse models. Vaccine candidate strains were developed by inserting the structural protein genes of WEEV strain McMillan (McM) or CO92-1356 into a Sindbis virus (SINV) strain AR339 backbone. The SIN/McM chimera also derived the N-terminal half of its capsid gene from a North American eastern equine encephalitis virus (EEEV) strain FL39-939 (henceforth referred to as SIN/EEE/McM). Although these vaccines do not generate viremia in mice, we further assessed their safety by exposing Cx. tarsalis to artificial blood meals containing high viral titers of each vaccine candidate. Both viruses exhibited a decreased rate of infection, dissemination, and transmission potential compared with the parental alphaviruses. Specifically, SIN/CO92 infected 37% of mosquitoes and disseminated in 8%, but failed to reach the saliva of the mosquitoes. In contrast, the SIN/EEE/McM virus was unable to infect, disseminate, or be transmitted in the saliva of any mosquitoes. These findings suggest that both vaccine candidates are less competent than the parental strains to be transmitted by the primary mosquito vector, Cx. tarsalis, and are unlikely to be reintroduced into a natural WEEV transmission cycle." @default.
• W2124342675 created "2016-06-24" @default.
• W2124342675 creator A5013244749 @default.
• W2124342675 creator A5032390019 @default.
• W2124342675 creator A5043018676 @default.
• W2124342675 date "2010-02-01" @default.
• W2124342675 modified "2023-10-15" @default.
• W2124342675 title "Transmission Potential of Two Chimeric Western Equine Encephalitis Vaccine Candidates in Culex tarsalis" @default.
• W2124342675 cites W1565923748 @default.
• W2124342675 cites W1933477094 @default.
• W2124342675 cites W1995019948 @default.
• W2124342675 cites W2006363902 @default.
• W2124342675 cites W2042093410 @default.
• W2124342675 cites W2044526352 @default.
• W2124342675 cites W2059493723 @default.
• W2124342675 cites W2078100710 @default.
• W2124342675 cites W2083291503 @default.
• W2124342675 cites W2083378196 @default.
• W2124342675 cites W2100616899 @default.
• W2124342675 cites W2126650840 @default.
• W2124342675 cites W2127658975 @default.
• W2124342675 cites W2152698100 @default.
• W2124342675 cites W2156623624 @default.
• W2124342675 cites W2160738740 @default.
• W2124342675 cites W2290368720 @default.
• W2124342675 cites W2403591290 @default.
• W2124342675 cites W2415402404 @default.
• W2124342675 cites W2415645706 @default.
• W2124342675 cites W2424467918 @default.
• W2124342675 cites W2436615407 @default.
• W2124342675 cites W2488306913 @default.
• W2124342675 cites W309298034 @default.
• W2124342675 doi "https://doi.org/10.4269/ajtmh.2010.09-0092" @default.
• W2124342675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2813181" @default.
• W2124342675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20134017" @default.
• W2124342675 hasPublicationYear "2010" @default.
• W2124342675 type Work @default.
• W2124342675 sameAs 2124342675 @default.
• W2124342675 citedByCount "8" @default.
• W2124342675 countsByYear W21243426752020 @default.
• W2124342675 countsByYear W21243426752021 @default.
• W2124342675 countsByYear W21243426752022 @default.
• W2124342675 crossrefType "journal-article" @default.
• W2124342675 hasAuthorship W2124342675A5013244749 @default.
• W2124342675 hasAuthorship W2124342675A5032390019 @default.
• W2124342675 hasAuthorship W2124342675A5043018676 @default.
• W2124342675 hasBestOaLocation W21243426751 @default.
• W2124342675 hasConcept C104317684 @default.
• W2124342675 hasConcept C159047783 @default.
• W2124342675 hasConcept C163698547 @default.
• W2124342675 hasConcept C2522874641 @default.
• W2124342675 hasConcept C2776185481 @default.
• W2124342675 hasConcept C2777062976 @default.
• W2124342675 hasConcept C2777343345 @default.
• W2124342675 hasConcept C2777474056 @default.
• W2124342675 hasConcept C2778116200 @default.
• W2124342675 hasConcept C2779755945 @default.
• W2124342675 hasConcept C40767141 @default.
• W2124342675 hasConcept C54355233 @default.
• W2124342675 hasConcept C54602769 @default.
• W2124342675 hasConcept C60987743 @default.
• W2124342675 hasConcept C67705224 @default.
• W2124342675 hasConcept C83455156 @default.
• W2124342675 hasConcept C86803240 @default.
• W2124342675 hasConcept C92087593 @default.
• W2124342675 hasConceptScore W2124342675C104317684 @default.
• W2124342675 hasConceptScore W2124342675C159047783 @default.
• W2124342675 hasConceptScore W2124342675C163698547 @default.
• W2124342675 hasConceptScore W2124342675C2522874641 @default.
• W2124342675 hasConceptScore W2124342675C2776185481 @default.
• W2124342675 hasConceptScore W2124342675C2777062976 @default.
• W2124342675 hasConceptScore W2124342675C2777343345 @default.
• W2124342675 hasConceptScore W2124342675C2777474056 @default.
• W2124342675 hasConceptScore W2124342675C2778116200 @default.
• W2124342675 hasConceptScore W2124342675C2779755945 @default.
• W2124342675 hasConceptScore W2124342675C40767141 @default.
• W2124342675 hasConceptScore W2124342675C54355233 @default.
• W2124342675 hasConceptScore W2124342675C54602769 @default.
• W2124342675 hasConceptScore W2124342675C60987743 @default.
• W2124342675 hasConceptScore W2124342675C67705224 @default.
• W2124342675 hasConceptScore W2124342675C83455156 @default.
• W2124342675 hasConceptScore W2124342675C86803240 @default.
• W2124342675 hasConceptScore W2124342675C92087593 @default.
• W2124342675 hasIssue "2" @default.
• W2124342675 hasLocation W21243426751 @default.
• W2124342675 hasLocation W21243426752 @default.
• W2124342675 hasLocation W21243426753 @default.
• W2124342675 hasLocation W21243426754 @default.
• W2124342675 hasOpenAccess W2124342675 @default.
• W2124342675 hasPrimaryLocation W21243426751 @default.
• W2124342675 hasRelatedWork W1452174070 @default.
• W2124342675 hasRelatedWork W1933588764 @default.
• W2124342675 hasRelatedWork W2009750207 @default.
• W2124342675 hasRelatedWork W2026634313 @default.
• W2124342675 hasRelatedWork W2033060346 @default.
• W2124342675 hasRelatedWork W2063622168 @default.
• W2124342675 hasRelatedWork W2078100710 @default.
• W2124342675 hasRelatedWork W2124342675 @default.

• next