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• W2124345404 abstract "Canonical Wnt signaling converts the TCF/LEF transcription factor from repressor to activator by increasing nuclear levels of its coactivator, beta-catenin. A striking exception had been reported for Wnt-induced endoderm formation during C. elegans embryogenesis. It has long been believed that transcriptional activation of Wnt target genes in the endoderm precursor occurred due to a lowering of nuclear levels of the worm TCF/LEF protein, POP-1, effectively alleviating POP-1 repressive activity. Contrary to this model, we demonstrate here that POP-1 directly activates Wnt target genes in the endoderm precursor. Wnt converts POP-1 from a repressor to an activator, and this conversion requires that POP-1 nuclear levels be lowered in the endoderm precursor. We propose that the balance between TCF/LEF and coactivator(s), achieved by elevating coactivator levels (the canonical pathway) and/or reducing TCF/LEF levels (worm endoderm), determines Wnt signal strength." @default.
• W2124345404 created "2016-06-24" @default.
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• W2124345404 date "2005-09-01" @default.
• W2124345404 modified "2023-10-17" @default.
• W2124345404 title "C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels" @default.
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• W2124345404 doi "https://doi.org/10.1016/j.ydbio.2005.07.008" @default.
• W2124345404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16112103" @default.
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