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- W2124348536 abstract "The effect of the L-fucose-selective lectin Ulex Europeus I (UEA I), a blocker of the Na+, K+, Cl- co-transport system in the kidney, was tested on insulin secretion from isolated beta-cell-rich pancreatic islets. UEA I at doses from 50 to 100 micrograms ml-1 significantly reduced the glucose-induced (20 mmol l-1) insulin release whereas the basal (3 mmol l-1) release was unaffected. The inhibitory effect of 100 micrograms ml l-1 UEA I was completely abolished by 10 mmol l-1 L-fucose. The data suggest that an L-fucose-containing structure in the beta-cell plasma membrane participates in the regulation of glucose-induced insulin release. This structure may be similar to the L-fucose-containing glycoprotein in the kidney tubules that is believed to be the Na+, K+, Cl- cotransporter." @default.
- W2124348536 created "2016-06-24" @default.
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- W2124348536 date "1998-12-01" @default.
- W2124348536 modified "2023-09-27" @default.
- W2124348536 title "Evidence that an L-fucose-containing component in the β-cellplasma membrane is involved in the regulation of glucose-induced insulin release" @default.
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- W2124348536 doi "https://doi.org/10.1111/j.1748-1716.1998.tb08531.x" @default.
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