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- W2124349744 abstract "The current outbreak of inhalation anthrax has some characteristics that are different from the epidemic of 1957 in the goat hair processing plant. In the 1957 epidemic, the employees worked in an environment in which there was significant contamination with Bacillus anthracis, as well as with other air borne pollutants, yet the incidence of inhalation anthrax was very low, and only occasional cases of cutaneous anthrax developed. In the current outbreak, we do not know the quantity of the aerosols to which people are being exposed, nor do we know with certainty the environmental area in which the aerosol was present. Without better denominator data, we are unable to compare attack rates. The clinical presentation of today’s inhalation cases are somewhat different from what we described in 1957. Some of these differences undoubtedly represent more rapid diagnosis and better care, including rapid treatment with more efficacious antibiotics. Do these differences reflect the specific organism or the dosage or some other factor? Also, the literature on cutaneous anthrax describes the need for the organisms to have a route through the epidermis; in the current cases, the route of entrance is not clear. Finally, in past studies in processing mills, the carriage rate of B. anthracis in the naries and in the pharynx was 14% without the development of any disease ascribed to the organism. We do not know the significance of positive nasal swabs in the current outbreak. As more data become available, there is much to be learned that will modify our knowledge of anthrax, both inhalation and cutaneous." @default.
- W2124349744 created "2016-06-24" @default.
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- W2124349744 date "2002-01-01" @default.
- W2124349744 modified "2023-10-18" @default.
- W2124349744 title "Inhalation anthrax revisited: a note from the original authors" @default.
- W2124349744 doi "https://doi.org/10.1016/s0002-9343(01)01076-2" @default.
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