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- W2124364042 abstract "Aim . We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods . A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagliptin or placebo after surgery for 4 days. The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery. Results . Sixty-two patients participated. Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mn>147.2</mml:mn><mml:mo>±</mml:mo><mml:mn>4.8</mml:mn></mml:mrow></mml:math> mg/dL and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mn>153.0</mml:mn><mml:mo>±</mml:mo><mml:mn>4.6</mml:mn></mml:mrow></mml:math> mg/dL for the test and the control group, respectively (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.388</mml:mn></mml:mrow></mml:math>). Conclusions . Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting." @default.
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- W2124364042 date "2012-01-01" @default.
- W2124364042 modified "2023-09-27" @default.
- W2124364042 title "Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study" @default.
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- W2124364042 doi "https://doi.org/10.1155/2012/810926" @default.
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