Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124365637> ?p ?o ?g. }
- W2124365637 abstract "Antisense oligonucleotides as a therapeutic platform have been slow to progress since the approval of the first antisense drug in 1998. Recently, there have been several examples of convincing antisense interventions in animal models and promising clinical trial data. This review considers the factors determining the success of antisense oligonucleotides as therapeutic agents. In order to produce target knockdown after systemic delivery, antisense oligonucleotides must avoid nuclease degradation, reticuloendothelial-system uptake and rapid renal excretion, and extravasate to the target cell type outside the vasculature. They then must enter the target cell, and escape the endosome-lysosome pathway so as to be free to interact with the target mRNA. We consider the significance of these limiting factors based on the literature and our own experience using systemic administration of antisense oligonucleotides." @default.
- W2124365637 created "2016-06-24" @default.
- W2124365637 creator A5012711579 @default.
- W2124365637 creator A5018807281 @default.
- W2124365637 creator A5021271630 @default.
- W2124365637 creator A5037277601 @default.
- W2124365637 date "2009-03-01" @default.
- W2124365637 modified "2023-10-18" @default.
- W2124365637 title "Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides" @default.
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