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- W2124374312 abstract "This chapter evaluates the available knowledge of simian virus 40 (SV40) oncogenesis and assesses the implications for carcinogenesis by DNA-tumor viruses as a whole. It summarizes different tests that can be employed to detect virus-induced changes in SV40-transformed cells. Inoculation of such cells into susceptible hosts usually results in the production of tumors, the ultimate criterion necessary to establish that malignant transformation has indeed occurred. Fusion or cocultivation of the transformed cell with normal susceptible cells may sometimes succeed in the rescue of infectious virus. The optimum conditions required to elicit the production of virus from a majority of the transformed cells have not yet been established. Transformed cells are usually immune to superinfection by the transforming virus. Nucleic acid hybridization experiments indicate that multiple copies of the SV40 genome is present, probably integrated into the host cell chromosome. Virus-specific mRNA is present in the transformed cells. The extent of the transcription of the viral genome seems to vary from one transformed cell line to the next. No relationships have been established between the extent of transcription in a given transformed cell line and the number and/or magnitude of virus-specific changes of that cell line. A series of in vitro tests may detect a variety of surface changes on the transformed cells. These tests include immunofluorescence, agglutination, cytotoxicity, colony inhibition, and mixed hemadsorption." @default.
- W2124374312 created "2016-06-24" @default.
- W2124374312 creator A5068608774 @default.
- W2124374312 creator A5070295719 @default.
- W2124374312 creator A5076330048 @default.
- W2124374312 date "1972-01-01" @default.
- W2124374312 modified "2023-09-27" @default.
- W2124374312 title "Oncogenicity And Cell Transformation By Papovavirus SV40: The Role Of The Viral Genome" @default.
- W2124374312 cites W1486969772 @default.
- W2124374312 cites W1490534637 @default.
- W2124374312 cites W1503067589 @default.
- W2124374312 cites W1504484016 @default.
- W2124374312 cites W1518325474 @default.
- W2124374312 cites W1525796911 @default.
- W2124374312 cites W1533844226 @default.
- W2124374312 cites W1545491074 @default.
- W2124374312 cites W1546274167 @default.
- W2124374312 cites W1548025758 @default.
- W2124374312 cites W1554961232 @default.
- W2124374312 cites W1555729813 @default.
- W2124374312 cites W1557917704 @default.
- W2124374312 cites W1559637898 @default.
- W2124374312 cites W1559815351 @default.
- W2124374312 cites W1562263846 @default.
- W2124374312 cites W1563598610 @default.
- W2124374312 cites W1573289384 @default.
- W2124374312 cites W1579662482 @default.
- W2124374312 cites W1592941518 @default.
- W2124374312 cites W1598197293 @default.
- W2124374312 cites W1602880261 @default.
- W2124374312 cites W1604284947 @default.
- W2124374312 cites W1605955282 @default.
- W2124374312 cites W1606234356 @default.
- W2124374312 cites W1617420288 @default.
- W2124374312 cites W1622512640 @default.
- W2124374312 cites W1639925154 @default.
- W2124374312 cites W164332614 @default.
- W2124374312 cites W1747991706 @default.
- W2124374312 cites W1748558454 @default.
- W2124374312 cites W1755503577 @default.
- W2124374312 cites W1767314125 @default.
- W2124374312 cites W1772500500 @default.
- W2124374312 cites W1884954392 @default.
- W2124374312 cites W1929197267 @default.
- W2124374312 cites W1955139485 @default.
- W2124374312 cites W1963824544 @default.
- W2124374312 cites W1963949170 @default.
- W2124374312 cites W1965461182 @default.
- W2124374312 cites W1965472833 @default.
- W2124374312 cites W1967189147 @default.
- W2124374312 cites W1967446284 @default.
- W2124374312 cites W1968110341 @default.
- W2124374312 cites W1968977268 @default.
- W2124374312 cites W1969541388 @default.
- W2124374312 cites W1969730612 @default.
- W2124374312 cites W1970107967 @default.
- W2124374312 cites W1970472778 @default.
- W2124374312 cites W1970702589 @default.
- W2124374312 cites W1971293675 @default.
- W2124374312 cites W1972811451 @default.
- W2124374312 cites W1973157135 @default.
- W2124374312 cites W1974379113 @default.
- W2124374312 cites W1974811358 @default.
- W2124374312 cites W1975176453 @default.
- W2124374312 cites W1975596321 @default.
- W2124374312 cites W1977399702 @default.
- W2124374312 cites W1978365813 @default.
- W2124374312 cites W1978827935 @default.
- W2124374312 cites W1978903078 @default.
- W2124374312 cites W1980317426 @default.
- W2124374312 cites W1981976794 @default.
- W2124374312 cites W1982513271 @default.
- W2124374312 cites W1982733393 @default.
- W2124374312 cites W1983060585 @default.
- W2124374312 cites W1985180361 @default.
- W2124374312 cites W1985296773 @default.
- W2124374312 cites W1985482319 @default.
- W2124374312 cites W1985994027 @default.
- W2124374312 cites W1987991164 @default.
- W2124374312 cites W1991127194 @default.
- W2124374312 cites W1991293003 @default.
- W2124374312 cites W1991335023 @default.
- W2124374312 cites W1991528054 @default.
- W2124374312 cites W1992214979 @default.
- W2124374312 cites W1993956071 @default.
- W2124374312 cites W1993982922 @default.
- W2124374312 cites W1994953504 @default.
- W2124374312 cites W1995002223 @default.
- W2124374312 cites W1995804588 @default.
- W2124374312 cites W1996055400 @default.
- W2124374312 cites W1996743466 @default.
- W2124374312 cites W1996860539 @default.
- W2124374312 cites W1997351434 @default.
- W2124374312 cites W1998290353 @default.
- W2124374312 cites W1999006674 @default.
- W2124374312 cites W1999650923 @default.
- W2124374312 cites W1999671829 @default.
- W2124374312 cites W2000471952 @default.