FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124385268> ?p ?o ?g. }

• W2124385268 endingPage "e72924" @default.
• W2124385268 startingPage "e72924" @default.
• W2124385268 abstract "Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal. Zebrafish (Danio rerio) are a genetically tractable system to investigate cardiac morphogenesis. The use of Tg(fli1a:EGFP)y1 transgenic embryos allowed for delineation and two-dimensional reconstruction of the endocardium. This time-varying wall motion was then prescribed in a two-dimensional moving domain computational fluid dynamics (CFD) model, providing new insights into spatial and temporal variations in WSS and ∇P during cardiac development. The CFD simulations were validated with particle image velocimetry (PIV) across the atrioventricular (AV) canal, revealing an increase in both velocities and heart rates, but a decrease in the duration of atrial systole from early to later stages. At 20-30 hours post fertilization (hpf), simulation results revealed bidirectional WSS across the AV canal in the heart tube in response to peristaltic motion of the wall. At 40-50 hpf, the tube structure undergoes cardiac looping, accompanied by a nearly 3-fold increase in WSS magnitude. At 110-120 hpf, distinct AV valve, atrium, ventricle, and bulbus arteriosus form, accompanied by incremental increases in both WSS magnitude and ∇P, but a decrease in bi-directional flow. Laminar flow develops across the AV canal at 20-30 hpf, and persists at 110-120 hpf. Reynolds numbers at the AV canal increase from 0.07±0.03 at 20-30 hpf to 0.23±0.07 at 110-120 hpf (p< 0.05, n=6), whereas Womersley numbers remain relatively unchanged from 0.11 to 0.13. Our moving domain simulations highlights hemodynamic changes in relation to cardiac morphogenesis; thereby, providing a 2-D quantitative approach to complement imaging analysis." @default.
• W2124385268 created "2016-06-24" @default.
• W2124385268 creator A5000067953 @default.
• W2124385268 creator A5000769574 @default.
• W2124385268 creator A5036422288 @default.
• W2124385268 creator A5037543869 @default.
• W2124385268 creator A5038366927 @default.
• W2124385268 creator A5043440558 @default.
• W2124385268 creator A5049080657 @default.
• W2124385268 creator A5071118240 @default.
• W2124385268 creator A5081322672 @default.
• W2124385268 creator A5083766821 @default.
• W2124385268 creator A5087790536 @default.
• W2124385268 date "2013-08-23" @default.
• W2124385268 modified "2023-09-24" @default.
• W2124385268 title "Moving Domain Computational Fluid Dynamics to Interface with an Embryonic Model of Cardiac Morphogenesis" @default.
• W2124385268 cites W1559457086 @default.
• W2124385268 cites W1968732273 @default.
• W2124385268 cites W1973018632 @default.
• W2124385268 cites W1976646890 @default.
• W2124385268 cites W1991323175 @default.
• W2124385268 cites W1992414825 @default.
• W2124385268 cites W1995746055 @default.
• W2124385268 cites W1996648013 @default.
• W2124385268 cites W2002970726 @default.
• W2124385268 cites W2004649896 @default.
• W2124385268 cites W2015180050 @default.
• W2124385268 cites W2018273895 @default.
• W2124385268 cites W2021554725 @default.
• W2124385268 cites W2023754092 @default.
• W2124385268 cites W2028340887 @default.
• W2124385268 cites W2029402099 @default.
• W2124385268 cites W2046625759 @default.
• W2124385268 cites W2056284641 @default.
• W2124385268 cites W2059796836 @default.
• W2124385268 cites W2062299875 @default.
• W2124385268 cites W2073119213 @default.
• W2124385268 cites W2073897969 @default.
• W2124385268 cites W2074442006 @default.
• W2124385268 cites W2081200148 @default.
• W2124385268 cites W2087988218 @default.
• W2124385268 cites W2089247555 @default.
• W2124385268 cites W2091393013 @default.
• W2124385268 cites W2096495823 @default.
• W2124385268 cites W2100031693 @default.
• W2124385268 cites W2101816987 @default.
• W2124385268 cites W2102186742 @default.
• W2124385268 cites W2115401766 @default.
• W2124385268 cites W2116082861 @default.
• W2124385268 cites W2126655313 @default.
• W2124385268 cites W2128316931 @default.
• W2124385268 cites W2128898632 @default.
• W2124385268 cites W2140153041 @default.
• W2124385268 cites W2154122281 @default.
• W2124385268 cites W2167808312 @default.
• W2124385268 cites W2171798492 @default.
• W2124385268 cites W2172014636 @default.
• W2124385268 doi "https://doi.org/10.1371/journal.pone.0072924" @default.
• W2124385268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3751826" @default.
• W2124385268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24009714" @default.
• W2124385268 hasPublicationYear "2013" @default.
• W2124385268 type Work @default.
• W2124385268 sameAs 2124385268 @default.
• W2124385268 citedByCount "50" @default.
• W2124385268 countsByYear W21243852682015 @default.
• W2124385268 countsByYear W21243852682016 @default.
• W2124385268 countsByYear W21243852682017 @default.
• W2124385268 countsByYear W21243852682018 @default.
• W2124385268 countsByYear W21243852682019 @default.
• W2124385268 countsByYear W21243852682020 @default.
• W2124385268 countsByYear W21243852682021 @default.
• W2124385268 countsByYear W21243852682022 @default.
• W2124385268 countsByYear W21243852682023 @default.
• W2124385268 crossrefType "journal-article" @default.
• W2124385268 hasAuthorship W2124385268A5000067953 @default.
• W2124385268 hasAuthorship W2124385268A5000769574 @default.
• W2124385268 hasAuthorship W2124385268A5036422288 @default.
• W2124385268 hasAuthorship W2124385268A5037543869 @default.
• W2124385268 hasAuthorship W2124385268A5038366927 @default.
• W2124385268 hasAuthorship W2124385268A5043440558 @default.
• W2124385268 hasAuthorship W2124385268A5049080657 @default.
• W2124385268 hasAuthorship W2124385268A5071118240 @default.
• W2124385268 hasAuthorship W2124385268A5081322672 @default.
• W2124385268 hasAuthorship W2124385268A5083766821 @default.
• W2124385268 hasAuthorship W2124385268A5087790536 @default.
• W2124385268 hasBestOaLocation W21243852681 @default.
• W2124385268 hasConcept C105702510 @default.
• W2124385268 hasConcept C121332964 @default.
• W2124385268 hasConcept C126322002 @default.
• W2124385268 hasConcept C136229726 @default.
• W2124385268 hasConcept C13852961 @default.
• W2124385268 hasConcept C1633027 @default.
• W2124385268 hasConcept C182748727 @default.
• W2124385268 hasConcept C192562407 @default.
• W2124385268 hasConcept C196558001 @default.
• W2124385268 hasConcept C207857233 @default.
• W2124385268 hasConcept C2778921608 @default.
• W2124385268 hasConcept C2780074459 @default.

• next