Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124402308> ?p ?o ?g. }
- W2124402308 endingPage "538" @default.
- W2124402308 startingPage "526" @default.
- W2124402308 abstract "Many enveloped viruses employ low-pH-triggered membrane fusion during cell penetration. Solution-based in vitro assays in which viruses fuse with liposomes have provided much of our current biochemical understanding of low-pH-triggered viral membrane fusion. Here, we extend this in vitro approach by introducing a fluorescence assay using single particle tracking to observe lipid mixing between individual virus particles (influenza or Sindbis) and supported lipid bilayers. Our single-particle experiments reproduce many of the observations of the solution assays. The single-particle approach naturally separates the processes of membrane binding and membrane fusion and therefore allows measurement of details that are not available in the bulk assays. We find that the dynamics of lipid mixing during individual Sindbis fusion events is faster than 30 ms. Although neither virus binds membranes at neutral pH, under acidic conditions, the delay between membrane binding and lipid mixing is less than half a second for nearly all virus-membrane combinations. The delay between binding and lipid mixing lengthened only for Sindbis virus at the lowest pH in a cholesterol-dependent manner, highlighting the complex interaction between lipids, virus proteins, and buffer conditions in membrane fusion." @default.
- W2124402308 created "2016-06-24" @default.
- W2124402308 creator A5002287842 @default.
- W2124402308 creator A5025516380 @default.
- W2124402308 creator A5048748003 @default.
- W2124402308 creator A5080802224 @default.
- W2124402308 date "2007-07-01" @default.
- W2124402308 modified "2023-10-14" @default.
- W2124402308 title "Rapid Membrane Fusion of Individual Virus Particles with Supported Lipid Bilayers" @default.
- W2124402308 cites W1492262300 @default.
- W2124402308 cites W1512995354 @default.
- W2124402308 cites W1525119362 @default.
- W2124402308 cites W1535209085 @default.
- W2124402308 cites W1536475774 @default.
- W2124402308 cites W1541186016 @default.
- W2124402308 cites W1550184056 @default.
- W2124402308 cites W1558058203 @default.
- W2124402308 cites W1600966607 @default.
- W2124402308 cites W1602346043 @default.
- W2124402308 cites W165359840 @default.
- W2124402308 cites W1766564474 @default.
- W2124402308 cites W1770280392 @default.
- W2124402308 cites W1852549140 @default.
- W2124402308 cites W1964339709 @default.
- W2124402308 cites W1964581455 @default.
- W2124402308 cites W1968563729 @default.
- W2124402308 cites W1969481779 @default.
- W2124402308 cites W1977006262 @default.
- W2124402308 cites W1977059850 @default.
- W2124402308 cites W1979661371 @default.
- W2124402308 cites W1983155620 @default.
- W2124402308 cites W1983404574 @default.
- W2124402308 cites W1986130046 @default.
- W2124402308 cites W1988762133 @default.
- W2124402308 cites W1990741897 @default.
- W2124402308 cites W1992141131 @default.
- W2124402308 cites W1998429632 @default.
- W2124402308 cites W1998597563 @default.
- W2124402308 cites W1999367496 @default.
- W2124402308 cites W2004008578 @default.
- W2124402308 cites W2005112039 @default.
- W2124402308 cites W2006040964 @default.
- W2124402308 cites W2009896070 @default.
- W2124402308 cites W2014030143 @default.
- W2124402308 cites W2014904556 @default.
- W2124402308 cites W2015611396 @default.
- W2124402308 cites W2015943547 @default.
- W2124402308 cites W2019162356 @default.
- W2124402308 cites W2021209936 @default.
- W2124402308 cites W2023720990 @default.
- W2124402308 cites W2027203404 @default.
- W2124402308 cites W2027744693 @default.
- W2124402308 cites W2029639174 @default.
- W2124402308 cites W2031432188 @default.
- W2124402308 cites W2033001398 @default.
- W2124402308 cites W2041593014 @default.
- W2124402308 cites W2042787593 @default.
- W2124402308 cites W2043060196 @default.
- W2124402308 cites W2046200533 @default.
- W2124402308 cites W2046254711 @default.
- W2124402308 cites W2056526910 @default.
- W2124402308 cites W2062961613 @default.
- W2124402308 cites W2065836616 @default.
- W2124402308 cites W2066383202 @default.
- W2124402308 cites W2068419533 @default.
- W2124402308 cites W2068971025 @default.
- W2124402308 cites W2069581273 @default.
- W2124402308 cites W2069655536 @default.
- W2124402308 cites W2074685112 @default.
- W2124402308 cites W2077192471 @default.
- W2124402308 cites W2078102644 @default.
- W2124402308 cites W2084610836 @default.
- W2124402308 cites W2089541173 @default.
- W2124402308 cites W2091001172 @default.
- W2124402308 cites W2094164512 @default.
- W2124402308 cites W2094569055 @default.
- W2124402308 cites W2095454778 @default.
- W2124402308 cites W2098868732 @default.
- W2124402308 cites W2102335249 @default.
- W2124402308 cites W2107913792 @default.
- W2124402308 cites W2117795938 @default.
- W2124402308 cites W2118155405 @default.
- W2124402308 cites W2121248674 @default.
- W2124402308 cites W2123151328 @default.
- W2124402308 cites W2124547357 @default.
- W2124402308 cites W2124948961 @default.
- W2124402308 cites W2127979877 @default.
- W2124402308 cites W2131476837 @default.
- W2124402308 cites W2133501340 @default.
- W2124402308 cites W2136265443 @default.
- W2124402308 cites W2147268838 @default.
- W2124402308 cites W2156163646 @default.
- W2124402308 cites W2164565944 @default.
- W2124402308 cites W2166312405 @default.
- W2124402308 cites W2166458266 @default.
- W2124402308 cites W2170902894 @default.
- W2124402308 cites W4206751571 @default.
- W2124402308 cites W4210958643 @default.