Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124407052> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2124407052 endingPage "1407" @default.
- W2124407052 startingPage "1403" @default.
- W2124407052 abstract "We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate the efficacy of oral treatment with MDL 27,695. L. donovani infections in BALB/c mice were suppressed greater than 99% after intraperitoneal dosing for 20 days with a total dose of 150 mg of MDL 27,695 per kg of body weight or 560 mg of Sbv per kg. Suppression was not increased by a total dose of 400 mg of MDL 27,695 per kg given for 20 days. In mice treated for 2, 4, or 7 days with either MDL 27,695 or Sbv (total doses of 60, 120, and 210 mg/kg, respectively), more liver parasites were killed with MDL 27,695 than with Sbv. Assessment of livers posttreatment showed that parasite killing continued for at least 3 days in MDL 27,695-treated mice but not for longer than 1 day in Sbv-treated mice. Intramuscular administration of drugs resulted in 92% parasite suppression by MDL 27,695 (15 mg/kg three times per day for 5 days) and 64% suppression by Sbv (60 mg/kg once per day for 5 days). Dosing of mice by oral gavage with 100 mg of MDL 27,695 per kg twice per day for 14 days resulted in 99.7% parasite suppression, and the 50% effective dose was approximately 11 mg of MDL 27,695 per kg. MDL 27,695 represents an effective new drug potentially useful for oral or parenteral treatment of visceral leishmaniasis." @default.
- W2124407052 created "2016-06-24" @default.
- W2124407052 creator A5005411107 @default.
- W2124407052 creator A5086034808 @default.
- W2124407052 creator A5089288203 @default.
- W2124407052 date "1991-07-01" @default.
- W2124407052 modified "2023-10-03" @default.
- W2124407052 title "Suppression of Leishmania donovani by oral administration of a bis(benzyl)polyamine analog" @default.
- W2124407052 cites W1963536763 @default.
- W2124407052 cites W1971536532 @default.
- W2124407052 cites W1977013453 @default.
- W2124407052 cites W1984360037 @default.
- W2124407052 cites W1988408881 @default.
- W2124407052 cites W1999809189 @default.
- W2124407052 cites W2003440976 @default.
- W2124407052 cites W2004071571 @default.
- W2124407052 cites W2009028465 @default.
- W2124407052 cites W2058637638 @default.
- W2124407052 cites W2083678132 @default.
- W2124407052 cites W2084233359 @default.
- W2124407052 cites W2112356357 @default.
- W2124407052 cites W2149447688 @default.
- W2124407052 cites W2151176434 @default.
- W2124407052 cites W2325086316 @default.
- W2124407052 cites W2410566671 @default.
- W2124407052 cites W2436545150 @default.
- W2124407052 cites W2486027309 @default.
- W2124407052 cites W2951561325 @default.
- W2124407052 cites W73866416 @default.
- W2124407052 doi "https://doi.org/10.1128/aac.35.7.1403" @default.
- W2124407052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245180" @default.
- W2124407052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1929300" @default.
- W2124407052 hasPublicationYear "1991" @default.
- W2124407052 type Work @default.
- W2124407052 sameAs 2124407052 @default.
- W2124407052 citedByCount "24" @default.
- W2124407052 countsByYear W21244070522013 @default.
- W2124407052 countsByYear W21244070522021 @default.
- W2124407052 countsByYear W21244070522022 @default.
- W2124407052 crossrefType "journal-article" @default.
- W2124407052 hasAuthorship W2124407052A5005411107 @default.
- W2124407052 hasAuthorship W2124407052A5086034808 @default.
- W2124407052 hasAuthorship W2124407052A5089288203 @default.
- W2124407052 hasBestOaLocation W21244070522 @default.
- W2124407052 hasConcept C112705442 @default.
- W2124407052 hasConcept C150903083 @default.
- W2124407052 hasConcept C203014093 @default.
- W2124407052 hasConcept C207001950 @default.
- W2124407052 hasConcept C2776555147 @default.
- W2124407052 hasConcept C2777056448 @default.
- W2124407052 hasConcept C2777288759 @default.
- W2124407052 hasConcept C2778689377 @default.
- W2124407052 hasConcept C2781333301 @default.
- W2124407052 hasConcept C71924100 @default.
- W2124407052 hasConcept C86803240 @default.
- W2124407052 hasConcept C98274493 @default.
- W2124407052 hasConceptScore W2124407052C112705442 @default.
- W2124407052 hasConceptScore W2124407052C150903083 @default.
- W2124407052 hasConceptScore W2124407052C203014093 @default.
- W2124407052 hasConceptScore W2124407052C207001950 @default.
- W2124407052 hasConceptScore W2124407052C2776555147 @default.
- W2124407052 hasConceptScore W2124407052C2777056448 @default.
- W2124407052 hasConceptScore W2124407052C2777288759 @default.
- W2124407052 hasConceptScore W2124407052C2778689377 @default.
- W2124407052 hasConceptScore W2124407052C2781333301 @default.
- W2124407052 hasConceptScore W2124407052C71924100 @default.
- W2124407052 hasConceptScore W2124407052C86803240 @default.
- W2124407052 hasConceptScore W2124407052C98274493 @default.
- W2124407052 hasIssue "7" @default.
- W2124407052 hasLocation W21244070521 @default.
- W2124407052 hasLocation W21244070522 @default.
- W2124407052 hasLocation W21244070523 @default.
- W2124407052 hasOpenAccess W2124407052 @default.
- W2124407052 hasPrimaryLocation W21244070521 @default.
- W2124407052 hasRelatedWork W1491964893 @default.
- W2124407052 hasRelatedWork W2004325424 @default.
- W2124407052 hasRelatedWork W2004556784 @default.
- W2124407052 hasRelatedWork W2010701854 @default.
- W2124407052 hasRelatedWork W2388069209 @default.
- W2124407052 hasRelatedWork W2414263157 @default.
- W2124407052 hasRelatedWork W2582907174 @default.
- W2124407052 hasRelatedWork W2753834235 @default.
- W2124407052 hasRelatedWork W2793520024 @default.
- W2124407052 hasRelatedWork W3021369409 @default.
- W2124407052 hasVolume "35" @default.
- W2124407052 isParatext "false" @default.
- W2124407052 isRetracted "false" @default.
- W2124407052 magId "2124407052" @default.
- W2124407052 workType "article" @default.