Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124436963> ?p ?o ?g. }
- W2124436963 abstract "Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here we show that podosomes of human dendritic cells locate to spots of low physical resistance in the substrate (soft spots) where they can evolve into protrusive structures. Pathogen recognition receptors locate to these protrusive structures where they can trigger localized antigen uptake, processing and presentation to activate T-cells. Our data demonstrate a novel role in antigen sampling for podosomes of dendritic cells." @default.
- W2124436963 created "2016-06-24" @default.
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- W2124436963 date "2014-01-01" @default.
- W2124436963 modified "2023-09-24" @default.
- W2124436963 title "Podosomes of dendritic cells facilitate antigen sampling" @default.
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- W2124436963 doi "https://doi.org/10.1242/jcs.141226" @default.
- W2124436963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4054684" @default.
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