FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124446098> ?p ?o ?g. }

• W2124446098 endingPage "e88795" @default.
• W2124446098 startingPage "e88795" @default.
• W2124446098 abstract "Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and assess how they affect NB cell behavior. The different gene expression found in 10 MYCN amplification NB tumors and 10 tumors with normal MYCN copy number were analyzed using tissue oligonucleotide microarrays. Ingenuity Pathway Analysis was subsequently performed to identify the potential genes involved in MYCN regulation pathways. Aryl hydrocarbon receptor (AHR), a receptor for dioxin-like compounds, was found to be inversely correlated with MYCN expression in NB tissues. This correlation was confirmed in a further 14 human NB samples. Moreover, AHR expression in NB tumors was found to correlate highly with histological grade of differentiation. In vitro studies revealed that AHR overexpression in NB cells induced spontaneous cell differentiation. In addition, it was found that ectopic expression of AHR suppressed MYCN promoter activity resulting in downregulation of MYCN expression. The suppression effect of AHR on the transcription of MYCN was compensated for by E2F1 overexpression, indicating that E2F1 is involved in the AHR-regulating MYCN pathway. Furthermore, AHR shRNA promotes the expression of E2F1 and MYCN in NB cells. These findings suggest that AHR is one of the upstream regulators of MYCN. Through the modulation of E2F1, AHR regulates MYCN gene expression, which may in turn affect NB differentiation." @default.
• W2124446098 created "2016-06-24" @default.
• W2124446098 creator A5013129253 @default.
• W2124446098 creator A5022121854 @default.
• W2124446098 creator A5027838493 @default.
• W2124446098 creator A5029524879 @default.
• W2124446098 creator A5035528811 @default.
• W2124446098 creator A5041630702 @default.
• W2124446098 creator A5044516889 @default.
• W2124446098 creator A5052313712 @default.
• W2124446098 creator A5059491102 @default.
• W2124446098 creator A5077809487 @default.
• W2124446098 creator A5081717889 @default.
• W2124446098 date "2014-02-21" @default.
• W2124446098 modified "2023-10-16" @default.
• W2124446098 title "Aryl Hydrocarbon Receptor Downregulates MYCN Expression and Promotes Cell Differentiation of Neuroblastoma" @default.
• W2124446098 cites W1481014355 @default.
• W2124446098 cites W1501696800 @default.
• W2124446098 cites W1828790967 @default.
• W2124446098 cites W1951128322 @default.
• W2124446098 cites W1963687870 @default.
• W2124446098 cites W1974123397 @default.
• W2124446098 cites W1981834434 @default.
• W2124446098 cites W1989986502 @default.
• W2124446098 cites W1996162026 @default.
• W2124446098 cites W2009938513 @default.
• W2124446098 cites W2010271798 @default.
• W2124446098 cites W2010372008 @default.
• W2124446098 cites W2016502540 @default.
• W2124446098 cites W2017516136 @default.
• W2124446098 cites W2034277114 @default.
• W2124446098 cites W2044261735 @default.
• W2124446098 cites W2053835256 @default.
• W2124446098 cites W2057364464 @default.
• W2124446098 cites W2059565720 @default.
• W2124446098 cites W2063647772 @default.
• W2124446098 cites W2067606868 @default.
• W2124446098 cites W2068125296 @default.
• W2124446098 cites W2068973221 @default.
• W2124446098 cites W2077340921 @default.
• W2124446098 cites W2080354412 @default.
• W2124446098 cites W2090922420 @default.
• W2124446098 cites W2093088098 @default.
• W2124446098 cites W2101300382 @default.
• W2124446098 cites W2101516334 @default.
• W2124446098 cites W2104456356 @default.
• W2124446098 cites W2110417418 @default.
• W2124446098 cites W2114264186 @default.
• W2124446098 cites W2121982330 @default.
• W2124446098 cites W2130617505 @default.
• W2124446098 cites W2133699042 @default.
• W2124446098 cites W2151384979 @default.
• W2124446098 cites W2156055427 @default.
• W2124446098 cites W2156531916 @default.
• W2124446098 cites W2162143298 @default.
• W2124446098 cites W2165627850 @default.
• W2124446098 cites W2317444302 @default.
• W2124446098 cites W2326401583 @default.
• W2124446098 cites W2791873134 @default.
• W2124446098 doi "https://doi.org/10.1371/journal.pone.0088795" @default.
• W2124446098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3931655" @default.
• W2124446098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586395" @default.
• W2124446098 hasPublicationYear "2014" @default.
• W2124446098 type Work @default.
• W2124446098 sameAs 2124446098 @default.
• W2124446098 citedByCount "24" @default.
• W2124446098 countsByYear W21244460982015 @default.
• W2124446098 countsByYear W21244460982016 @default.
• W2124446098 countsByYear W21244460982017 @default.
• W2124446098 countsByYear W21244460982018 @default.
• W2124446098 countsByYear W21244460982019 @default.
• W2124446098 countsByYear W21244460982020 @default.
• W2124446098 countsByYear W21244460982021 @default.
• W2124446098 countsByYear W21244460982022 @default.
• W2124446098 countsByYear W21244460982023 @default.
• W2124446098 crossrefType "journal-article" @default.
• W2124446098 hasAuthorship W2124446098A5013129253 @default.
• W2124446098 hasAuthorship W2124446098A5022121854 @default.
• W2124446098 hasAuthorship W2124446098A5027838493 @default.
• W2124446098 hasAuthorship W2124446098A5029524879 @default.
• W2124446098 hasAuthorship W2124446098A5035528811 @default.
• W2124446098 hasAuthorship W2124446098A5041630702 @default.
• W2124446098 hasAuthorship W2124446098A5044516889 @default.
• W2124446098 hasAuthorship W2124446098A5052313712 @default.
• W2124446098 hasAuthorship W2124446098A5059491102 @default.
• W2124446098 hasAuthorship W2124446098A5077809487 @default.
• W2124446098 hasAuthorship W2124446098A5081717889 @default.
• W2124446098 hasBestOaLocation W21244460981 @default.
• W2124446098 hasConcept C104317684 @default.
• W2124446098 hasConcept C127561419 @default.
• W2124446098 hasConcept C148738053 @default.
• W2124446098 hasConcept C150194340 @default.
• W2124446098 hasConcept C173396325 @default.
• W2124446098 hasConcept C183022183 @default.
• W2124446098 hasConcept C2776715637 @default.
• W2124446098 hasConcept C33594762 @default.
• W2124446098 hasConcept C502942594 @default.
• W2124446098 hasConcept C54355233 @default.

• next