FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124454060> ?p ?o ?g. }

• W2124454060 abstract "This work uses a novel heart-perfusion technique to measure [ 3 H]-lipopolysaccharide ([ 3 H]-LPS) binding on capillary endothelium and myocyte cell membranes in Sprague-Dawley rats. Free or serum-containing Ringer-Lock buffer was infused at a rate of 1 ml/min and in the presence of 20 mM K + and [ 3 H]-LPS through an aortic cannula, and the effluent was collected through a catheter introduced into the right atrium cavity. The capillary endothelial lining was removed by CHAPS treatment to expose the cardiac myocyte surface. A physical model describing 1:1 binding stoichiometry of [ 3 H]-LPS with its receptors is proposed and the mathematical equations derived allow for the calculation of binding constants (k n ), reversal constants (k -n ), dissociation constants (k d ), and residency time constants (τ). The results showed that the presence of serum in the perfusate, slowed the binding of [ 3 H]-LPS with the endothelial lining and myocytes, but increased the residency time by 3- and 50-fold, respectively. Hence, the endothelium and myofiber may contain LPS receptors that can bind more strongly with the ligand in association with sCD14-like and LBP-like molecules in rat serum. Thus it is postulated that the affinity of LPS to its receptor subtypes is not strictly and specifically dependent on the CD14 binding profile." @default.
• W2124454060 created "2016-06-24" @default.
• W2124454060 creator A5007549278 @default.
• W2124454060 creator A5025155391 @default.
• W2124454060 creator A5038864223 @default.
• W2124454060 creator A5042997432 @default.
• W2124454060 creator A5043019129 @default.
• W2124454060 creator A5057229693 @default.
• W2124454060 creator A5062203574 @default.
• W2124454060 date "1997-02-01" @default.
• W2124454060 modified "2023-09-27" @default.
• W2124454060 title "Endotoxin binding on capillary endothelium and myocyte plasma membranes in perfused rat heart" @default.
• W2124454060 cites W1582984670 @default.
• W2124454060 cites W1898252364 @default.
• W2124454060 cites W2021418970 @default.
• W2124454060 cites W2029157767 @default.
• W2124454060 cites W2049211452 @default.
• W2124454060 cites W2054208097 @default.
• W2124454060 cites W2064626913 @default.
• W2124454060 cites W2067294390 @default.
• W2124454060 cites W2074570851 @default.
• W2124454060 cites W2078025768 @default.
• W2124454060 cites W2113828544 @default.
• W2124454060 cites W2146668042 @default.
• W2124454060 cites W2146948320 @default.
• W2124454060 cites W2170495397 @default.
• W2124454060 doi "https://doi.org/10.1177/096805199700400106" @default.
• W2124454060 hasPublicationYear "1997" @default.
• W2124454060 type Work @default.
• W2124454060 sameAs 2124454060 @default.
• W2124454060 citedByCount "2" @default.
• W2124454060 crossrefType "journal-article" @default.
• W2124454060 hasAuthorship W2124454060A5007549278 @default.
• W2124454060 hasAuthorship W2124454060A5025155391 @default.
• W2124454060 hasAuthorship W2124454060A5038864223 @default.
• W2124454060 hasAuthorship W2124454060A5042997432 @default.
• W2124454060 hasAuthorship W2124454060A5043019129 @default.
• W2124454060 hasAuthorship W2124454060A5057229693 @default.
• W2124454060 hasAuthorship W2124454060A5062203574 @default.
• W2124454060 hasConcept C123012128 @default.
• W2124454060 hasConcept C12554922 @default.
• W2124454060 hasConcept C126322002 @default.
• W2124454060 hasConcept C141071460 @default.
• W2124454060 hasConcept C146957229 @default.
• W2124454060 hasConcept C159985019 @default.
• W2124454060 hasConcept C170493617 @default.
• W2124454060 hasConcept C185592680 @default.
• W2124454060 hasConcept C192562407 @default.
• W2124454060 hasConcept C196806460 @default.
• W2124454060 hasConcept C202751555 @default.
• W2124454060 hasConcept C207200792 @default.
• W2124454060 hasConcept C2776992346 @default.
• W2124454060 hasConcept C2778074680 @default.
• W2124454060 hasConcept C41625074 @default.
• W2124454060 hasConcept C55493867 @default.
• W2124454060 hasConcept C71924100 @default.
• W2124454060 hasConcept C74998103 @default.
• W2124454060 hasConcept C86803240 @default.
• W2124454060 hasConceptScore W2124454060C123012128 @default.
• W2124454060 hasConceptScore W2124454060C12554922 @default.
• W2124454060 hasConceptScore W2124454060C126322002 @default.
• W2124454060 hasConceptScore W2124454060C141071460 @default.
• W2124454060 hasConceptScore W2124454060C146957229 @default.
• W2124454060 hasConceptScore W2124454060C159985019 @default.
• W2124454060 hasConceptScore W2124454060C170493617 @default.
• W2124454060 hasConceptScore W2124454060C185592680 @default.
• W2124454060 hasConceptScore W2124454060C192562407 @default.
• W2124454060 hasConceptScore W2124454060C196806460 @default.
• W2124454060 hasConceptScore W2124454060C202751555 @default.
• W2124454060 hasConceptScore W2124454060C207200792 @default.
• W2124454060 hasConceptScore W2124454060C2776992346 @default.
• W2124454060 hasConceptScore W2124454060C2778074680 @default.
• W2124454060 hasConceptScore W2124454060C41625074 @default.
• W2124454060 hasConceptScore W2124454060C55493867 @default.
• W2124454060 hasConceptScore W2124454060C71924100 @default.
• W2124454060 hasConceptScore W2124454060C74998103 @default.
• W2124454060 hasConceptScore W2124454060C86803240 @default.
• W2124454060 hasLocation W21244540601 @default.
• W2124454060 hasOpenAccess W2124454060 @default.
• W2124454060 hasPrimaryLocation W21244540601 @default.
• W2124454060 hasRelatedWork W1981416001 @default.
• W2124454060 hasRelatedWork W1990258002 @default.
• W2124454060 hasRelatedWork W1994855224 @default.
• W2124454060 hasRelatedWork W2004511689 @default.
• W2124454060 hasRelatedWork W2012305079 @default.
• W2124454060 hasRelatedWork W2045049378 @default.
• W2124454060 hasRelatedWork W2071185985 @default.
• W2124454060 hasRelatedWork W2077106623 @default.
• W2124454060 hasRelatedWork W2079508770 @default.
• W2124454060 hasRelatedWork W2092427910 @default.
• W2124454060 hasRelatedWork W2106072631 @default.
• W2124454060 hasRelatedWork W2141289674 @default.
• W2124454060 hasRelatedWork W2296095520 @default.
• W2124454060 hasRelatedWork W2373181703 @default.
• W2124454060 hasRelatedWork W2995571484 @default.
• W2124454060 hasRelatedWork W3105980805 @default.
• W2124454060 hasRelatedWork W34506114 @default.
• W2124454060 hasRelatedWork W600108960 @default.
• W2124454060 hasRelatedWork W66822305 @default.
• W2124454060 hasRelatedWork W3159924924 @default.

• next