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• W2124455112 abstract "Cl- ions are known regulators of Ca2+ -dependent secretory activity in many endocrine cells. The suggested mechanisms of Cl- action involve the modulation of GTP-binding proteins, voltage-activated calcium channels or maturation of secretory vesicles. We examined the role of cytosolic Cl- ([Cl-]i) and Cl- currents in the regulation of secretory activity in mouse melanotrophs from fresh pituitary tissue slices by using the whole-cell patch-clamp. We confirmed that elevated [Cl-]i augments Ca2- -dependent exocytosis and showed that Cl- acts on secretory vesicle maturation. The latter process was abolished by a V-type H- -ATPase blocker (bafilomycin), intracellular 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS), a Cl- channel blocker, and tolbutamide, a sulphonylurea implicated in secretory vesicle maturation. In a small subset of cells, block of plasmalemmal Cl- current by DIDS reversibly enhanced endocytosis. The direct activation of G-proteins by GTP-gamma-S, a non-hydrolysable GTP analogue, did not restore the impaired secretion observed in low [Cl-]i conditions. The amplitude of voltage-activated calcium currents was unaffected by the [Cl-]i. Furthermore, two Cl- -permeable channels, calcium-activated Cl- channels and GABAA receptors, appeared as major regulators of intracellular Cl- homeostasis. In conclusion, the predominant underlying mechanism of Cl- action is mediated by intracellular Cl- fluxes during vesicle maturation, rather than activation of G-proteins or modulation of voltage-activated Ca2+channels." @default.
• W2124455112 created "2016-06-24" @default.
• W2124455112 creator A5001441139 @default.
• W2124455112 creator A5030041504 @default.
• W2124455112 creator A5082405402 @default.
• W2124455112 date "2005-07-01" @default.
• W2124455112 modified "2023-10-12" @default.
• W2124455112 title "Cytosolic Cl⁻ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices" @default.
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• W2124455112 cites W1993373202 @default.
• W2124455112 cites W1994140164 @default.
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• W2124455112 cites W1997511216 @default.
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• W2124455112 doi "https://doi.org/10.1113/jphysiol.2005.088997" @default.
• W2124455112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1464753" @default.
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