FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124457688> ?p ?o ?g. }

• W2124457688 endingPage "R1286" @default.
• W2124457688 startingPage "R1279" @default.
• W2124457688 abstract "Elevated bladder smooth muscle cell (BSMC) nerve growth factor (NGF) secretion and related neuroplasticity are associated with hyperactive voiding in spontaneously hypertensive rats (SHRs: hypertensive, behaviorally hyperactive), compared with control Wistar-Kyotos (WKYs). We used two inbred strains (WKHT: hypertensive; WKHA: hyperactive) to further investigate this phenomenon. WKHA BSMCs secreted higher basal levels of NGF than WKHT BSMCs. Antagonists did inhibit NGF output in WKHA but not WKHT cultures. Thus augmented basal secretion of NGF cosegregates with a hyperactive phenotype, whereas a lack of regulatory inhibition of NGF output cosegregates with a hypertensive phenotype. Bladder norepinephrine content paralleled NGF content, with WKHTs > SHRs > WKHAs > WKYs, providing evidence that a lack of inhibition is the greatest contributor to elevated bladder NGF and noradrenergic innervation. Protein kinase C (PKC) agonists affected NGF production differentially depending on strain, suggesting that altered PKC signaling may contribute to strain differences in NGF secretion. Finally, 6-h voiding frequency differed between the strains, with SHRs > WKHTs = WKHAs > WKYs. Thus aspects of both the hypertensive and hyperactive phenotypes may be associated with elevated SHR bladder NGF and hyperactive voiding." @default.
• W2124457688 created "2016-06-24" @default.
• W2124457688 creator A5036999043 @default.
• W2124457688 creator A5038136326 @default.
• W2124457688 creator A5063292982 @default.
• W2124457688 creator A5069688414 @default.
• W2124457688 date "1998-10-01" @default.
• W2124457688 modified "2023-09-27" @default.
• W2124457688 title "Altered regulation of bladder nerve growth factor and neurally mediated hyperactive voiding" @default.
• W2124457688 cites W1762264738 @default.
• W2124457688 cites W1820192366 @default.
• W2124457688 cites W1840804593 @default.
• W2124457688 cites W1964189568 @default.
• W2124457688 cites W1965451339 @default.
• W2124457688 cites W1966357040 @default.
• W2124457688 cites W1972463231 @default.
• W2124457688 cites W1973101996 @default.
• W2124457688 cites W1974520470 @default.
• W2124457688 cites W1978663880 @default.
• W2124457688 cites W1981881657 @default.
• W2124457688 cites W1993623553 @default.
• W2124457688 cites W2007372074 @default.
• W2124457688 cites W2019095365 @default.
• W2124457688 cites W2035777044 @default.
• W2124457688 cites W2042435114 @default.
• W2124457688 cites W2044694592 @default.
• W2124457688 cites W2049844981 @default.
• W2124457688 cites W2087954307 @default.
• W2124457688 cites W2091345855 @default.
• W2124457688 cites W2101423394 @default.
• W2124457688 cites W2143561995 @default.
• W2124457688 cites W2148575936 @default.
• W2124457688 cites W2149134627 @default.
• W2124457688 cites W2164990421 @default.
• W2124457688 cites W76461109 @default.
• W2124457688 doi "https://doi.org/10.1152/ajpregu.1998.275.4.r1279" @default.
• W2124457688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9756561" @default.
• W2124457688 hasPublicationYear "1998" @default.
• W2124457688 type Work @default.
• W2124457688 sameAs 2124457688 @default.
• W2124457688 citedByCount "30" @default.
• W2124457688 countsByYear W21244576882012 @default.
• W2124457688 countsByYear W21244576882013 @default.
• W2124457688 countsByYear W21244576882014 @default.
• W2124457688 countsByYear W21244576882015 @default.
• W2124457688 countsByYear W21244576882016 @default.
• W2124457688 countsByYear W21244576882017 @default.
• W2124457688 countsByYear W21244576882018 @default.
• W2124457688 countsByYear W21244576882019 @default.
• W2124457688 countsByYear W21244576882021 @default.
• W2124457688 countsByYear W21244576882023 @default.
• W2124457688 crossrefType "journal-article" @default.
• W2124457688 hasAuthorship W2124457688A5036999043 @default.
• W2124457688 hasAuthorship W2124457688A5038136326 @default.
• W2124457688 hasAuthorship W2124457688A5063292982 @default.
• W2124457688 hasAuthorship W2124457688A5069688414 @default.
• W2124457688 hasConcept C104317684 @default.
• W2124457688 hasConcept C126322002 @default.
• W2124457688 hasConcept C127716648 @default.
• W2124457688 hasConcept C134018914 @default.
• W2124457688 hasConcept C170493617 @default.
• W2124457688 hasConcept C195794163 @default.
• W2124457688 hasConcept C2777540882 @default.
• W2124457688 hasConcept C2778024521 @default.
• W2124457688 hasConcept C2778423431 @default.
• W2124457688 hasConcept C2779306644 @default.
• W2124457688 hasConcept C2779762690 @default.
• W2124457688 hasConcept C49039625 @default.
• W2124457688 hasConcept C55493867 @default.
• W2124457688 hasConcept C62478195 @default.
• W2124457688 hasConcept C71924100 @default.
• W2124457688 hasConcept C86803240 @default.
• W2124457688 hasConcept C95444343 @default.
• W2124457688 hasConceptScore W2124457688C104317684 @default.
• W2124457688 hasConceptScore W2124457688C126322002 @default.
• W2124457688 hasConceptScore W2124457688C127716648 @default.
• W2124457688 hasConceptScore W2124457688C134018914 @default.
• W2124457688 hasConceptScore W2124457688C170493617 @default.
• W2124457688 hasConceptScore W2124457688C195794163 @default.
• W2124457688 hasConceptScore W2124457688C2777540882 @default.
• W2124457688 hasConceptScore W2124457688C2778024521 @default.
• W2124457688 hasConceptScore W2124457688C2778423431 @default.
• W2124457688 hasConceptScore W2124457688C2779306644 @default.
• W2124457688 hasConceptScore W2124457688C2779762690 @default.
• W2124457688 hasConceptScore W2124457688C49039625 @default.
• W2124457688 hasConceptScore W2124457688C55493867 @default.
• W2124457688 hasConceptScore W2124457688C62478195 @default.
• W2124457688 hasConceptScore W2124457688C71924100 @default.
• W2124457688 hasConceptScore W2124457688C86803240 @default.
• W2124457688 hasConceptScore W2124457688C95444343 @default.
• W2124457688 hasIssue "4" @default.
• W2124457688 hasLocation W21244576881 @default.
• W2124457688 hasLocation W21244576882 @default.
• W2124457688 hasOpenAccess W2124457688 @default.
• W2124457688 hasPrimaryLocation W21244576881 @default.
• W2124457688 hasRelatedWork W1969550954 @default.
• W2124457688 hasRelatedWork W2009854143 @default.
• W2124457688 hasRelatedWork W2016328345 @default.

• next