FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124458011> ?p ?o ?g. }

• W2124458011 endingPage "1003" @default.
• W2124458011 startingPage "993" @default.
• W2124458011 abstract "Alpha-synuclein has been reported to be present in the nucleus and levels enhanced by oxidative stress. Herein, we sought to investigate the mechanistic role of nuclear alpha-synuclein. We found that alpha-synuclein nuclear localization coincided with enhanced chromatin binding both in an in vitro and a corresponding in vivo brain oxidative stress model previously characterized by our laboratory as well as in PD brain tissues. Genome-wide chromatin immunoprecipitation (ChIP)-on-chip analysis of alpha-synuclein:promoter binding in response to oxidative stress in vitro revealed that binding occurs at several promoters belonging to a range of functional categories including transcriptional regulation. Interestingly, given the important role of mitochondrial dysfunction in PD, this included binding to the promoter for the master mitochondrial transcription activator, PGC1alpha in vitro, in vivo, and in human brain tissue with age and PD. To test the possible mechanistic impact of alpha-synuclein PGC1alpha promotor binding, we assessed PGC1alpha promoter activity, mRNA, and protein levels and expression of candidate PGC1alpha target genes in our in vitro model. All were found to be reduced in conjunction with increased levels of aberrant mitochondrial morphology and impaired mitochondrial function. Exogenous PGC1alpha expression was found to attenuate alpha-synuclein-mediated mitochondrial dysfunction and subsequent neurotoxicity in vitro. Our data suggest that nuclear alpha-synuclein localization under conditions of oxidative stress may impact on mitochondrial function in part via the protein's capacity to act as a transcriptional modulator of PGC1alpha. This represents a novel role for alpha-synuclein as it relates to mitochondrial dysfunction in PD." @default.
• W2124458011 created "2016-06-24" @default.
• W2124458011 creator A5034309972 @default.
• W2124458011 creator A5052966010 @default.
• W2124458011 creator A5057847016 @default.
• W2124458011 creator A5058536845 @default.
• W2124458011 creator A5059066848 @default.
• W2124458011 creator A5070230057 @default.
• W2124458011 creator A5074380141 @default.
• W2124458011 creator A5085303733 @default.
• W2124458011 date "2012-08-01" @default.
• W2124458011 modified "2023-10-01" @default.
• W2124458011 title "Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease" @default.
• W2124458011 cites W1569716332 @default.
• W2124458011 cites W1589792898 @default.
• W2124458011 cites W1900066504 @default.
• W2124458011 cites W1966691229 @default.
• W2124458011 cites W1979833383 @default.
• W2124458011 cites W1982520634 @default.
• W2124458011 cites W1983315832 @default.
• W2124458011 cites W1984576566 @default.
• W2124458011 cites W1991128766 @default.
• W2124458011 cites W1995354490 @default.
• W2124458011 cites W2001651274 @default.
• W2124458011 cites W2006463991 @default.
• W2124458011 cites W2006869862 @default.
• W2124458011 cites W2010304081 @default.
• W2124458011 cites W2012857688 @default.
• W2124458011 cites W2017785279 @default.
• W2124458011 cites W2018427433 @default.
• W2124458011 cites W2018907079 @default.
• W2124458011 cites W2023224520 @default.
• W2124458011 cites W2027986511 @default.
• W2124458011 cites W2032102101 @default.
• W2124458011 cites W2038524016 @default.
• W2124458011 cites W2040462263 @default.
• W2124458011 cites W2043024635 @default.
• W2124458011 cites W2045385554 @default.
• W2124458011 cites W2047565527 @default.
• W2124458011 cites W2050540467 @default.
• W2124458011 cites W2051579355 @default.
• W2124458011 cites W2052930127 @default.
• W2124458011 cites W2055029031 @default.
• W2124458011 cites W2055175471 @default.
• W2124458011 cites W2055923651 @default.
• W2124458011 cites W2058909419 @default.
• W2124458011 cites W2071391660 @default.
• W2124458011 cites W2074833985 @default.
• W2124458011 cites W2076890308 @default.
• W2124458011 cites W2079762064 @default.
• W2124458011 cites W2090999212 @default.
• W2124458011 cites W2124567863 @default.
• W2124458011 cites W2148641246 @default.
• W2124458011 cites W2154887758 @default.
• W2124458011 cites W2157952888 @default.
• W2124458011 cites W2158240093 @default.
• W2124458011 cites W2160697936 @default.
• W2124458011 cites W2161637965 @default.
• W2124458011 cites W2167678675 @default.
• W2124458011 cites W4248318091 @default.
• W2124458011 doi "https://doi.org/10.1016/j.freeradbiomed.2012.05.024" @default.
• W2124458011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418424" @default.
• W2124458011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705949" @default.
• W2124458011 hasPublicationYear "2012" @default.
• W2124458011 type Work @default.
• W2124458011 sameAs 2124458011 @default.
• W2124458011 citedByCount "149" @default.
• W2124458011 countsByYear W21244580112012 @default.
• W2124458011 countsByYear W21244580112013 @default.
• W2124458011 countsByYear W21244580112014 @default.
• W2124458011 countsByYear W21244580112015 @default.
• W2124458011 countsByYear W21244580112016 @default.
• W2124458011 countsByYear W21244580112017 @default.
• W2124458011 countsByYear W21244580112018 @default.
• W2124458011 countsByYear W21244580112019 @default.
• W2124458011 countsByYear W21244580112020 @default.
• W2124458011 countsByYear W21244580112021 @default.
• W2124458011 countsByYear W21244580112022 @default.
• W2124458011 countsByYear W21244580112023 @default.
• W2124458011 crossrefType "journal-article" @default.
• W2124458011 hasAuthorship W2124458011A5034309972 @default.
• W2124458011 hasAuthorship W2124458011A5052966010 @default.
• W2124458011 hasAuthorship W2124458011A5057847016 @default.
• W2124458011 hasAuthorship W2124458011A5058536845 @default.
• W2124458011 hasAuthorship W2124458011A5059066848 @default.
• W2124458011 hasAuthorship W2124458011A5070230057 @default.
• W2124458011 hasAuthorship W2124458011A5074380141 @default.
• W2124458011 hasAuthorship W2124458011A5085303733 @default.
• W2124458011 hasBestOaLocation W21244580112 @default.
• W2124458011 hasConcept C101762097 @default.
• W2124458011 hasConcept C104317684 @default.
• W2124458011 hasConcept C126322002 @default.
• W2124458011 hasConcept C134320426 @default.
• W2124458011 hasConcept C150194340 @default.
• W2124458011 hasConcept C153911025 @default.
• W2124458011 hasConcept C2776151105 @default.
• W2124458011 hasConcept C2779134260 @default.
• W2124458011 hasConcept C2779734285 @default.

• next