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• W2124460002 abstract "The co-morbidities of obesity are tied to location of excess fat in the intra-abdominal as compared to subcutaneous white adipose tissue (WAT) depot. Genes distinctly expressed in WAT depots may impart depot-dependent physiological functions. To identify such genes, we prepared subtractive cDNA libraries from murine subcutaneous (SC) or intra-abdominal epididymal (EP) white adipocytes.Differential screening and qPCR validation identified 7 transcripts with 2.5-fold or greater enrichment in EP vs. SC adipocytes. Boc, a component of the hedgehog signaling pathway demonstrated highest enrichment (approximately 12-fold) in EP adipocytes. We also identified a dramatic enrichment in SC adipocytes vs. EP adipocytes and in SC WAT vs. EP WAT for transcript(s) for the major urinary proteins (Mups), small secreted proteins with pheromone functions that are members of the lipocalin family. Expression of Boc and Mup transcript was further assessed in murine tissues, adipogenesis models, and obesity. qPCR analysis reveals that EP WAT is a major site of expression of Boc transcript. Furthermore, Boc transcript expression decreased in obese EP WAT with a concomitant upregulation of Boc transcript in the obese SC WAT depot. Assessment of the Boc binding partner Cdon in adipose tissue and cell fractions thereof, revealed transcript expression similar to Boc; suggestive of a role for the Boc-Cdon axis in WAT depot function. Mup transcripts were predominantly expressed in liver and in the SC and RP WAT depots and increased several thousand-fold during differentiation of primary murine preadipocytes to adipocytes. Mup transcripts were also markedly reduced in SC WAT and liver of ob/ob genetically obese mice compared to wild type.Further assessment of WAT depot-enriched transcripts may uncover distinctions in WAT depot gene expression that illuminate the physiological impact of regional adiposity." @default.
• W2124460002 created "2016-06-24" @default.
• W2124460002 creator A5003457704 @default.
• W2124460002 creator A5036629984 @default.
• W2124460002 creator A5061882986 @default.
• W2124460002 creator A5067915781 @default.
• W2124460002 date "2008-08-22" @default.
• W2124460002 modified "2023-10-17" @default.
• W2124460002 title "Differential screening identifies transcripts with depot-dependent expression in white adipose tissues" @default.
• W2124460002 cites W1494843064 @default.
• W2124460002 cites W1512840340 @default.
• W2124460002 cites W1547487330 @default.
• W2124460002 cites W1577577364 @default.
• W2124460002 cites W1867847851 @default.
• W2124460002 cites W1926712744 @default.
• W2124460002 cites W1965301379 @default.
• W2124460002 cites W1966507802 @default.
• W2124460002 cites W1971544693 @default.
• W2124460002 cites W1972091253 @default.
• W2124460002 cites W1972338781 @default.
• W2124460002 cites W1975435552 @default.
• W2124460002 cites W1977883364 @default.
• W2124460002 cites W1981064972 @default.
• W2124460002 cites W1982481323 @default.
• W2124460002 cites W1983917126 @default.
• W2124460002 cites W1983955010 @default.
• W2124460002 cites W1986503794 @default.
• W2124460002 cites W1990588947 @default.
• W2124460002 cites W1990593049 @default.
• W2124460002 cites W1991334358 @default.
• W2124460002 cites W1991374761 @default.
• W2124460002 cites W1991944268 @default.
• W2124460002 cites W2007236682 @default.
• W2124460002 cites W2016692980 @default.
• W2124460002 cites W2023034164 @default.
• W2124460002 cites W2029957148 @default.
• W2124460002 cites W2033693803 @default.
• W2124460002 cites W2033886769 @default.
• W2124460002 cites W2037316960 @default.
• W2124460002 cites W2037668125 @default.
• W2124460002 cites W2038438679 @default.
• W2124460002 cites W2039226625 @default.
• W2124460002 cites W2041828161 @default.
• W2124460002 cites W2045432341 @default.
• W2124460002 cites W2054965892 @default.
• W2124460002 cites W2055956383 @default.
• W2124460002 cites W2059511498 @default.
• W2124460002 cites W2060899732 @default.
• W2124460002 cites W2063238018 @default.
• W2124460002 cites W2065937314 @default.
• W2124460002 cites W2071242655 @default.
• W2124460002 cites W2072845551 @default.
• W2124460002 cites W2075494055 @default.
• W2124460002 cites W2079874684 @default.
• W2124460002 cites W2082269190 @default.
• W2124460002 cites W2082619868 @default.
• W2124460002 cites W2083487562 @default.
• W2124460002 cites W2084033509 @default.
• W2124460002 cites W2088235202 @default.
• W2124460002 cites W2089462451 @default.
• W2124460002 cites W2090204462 @default.
• W2124460002 cites W2092746889 @default.
• W2124460002 cites W2095516356 @default.
• W2124460002 cites W2098560713 @default.
• W2124460002 cites W2100363358 @default.
• W2124460002 cites W2100952064 @default.
• W2124460002 cites W2104033956 @default.
• W2124460002 cites W2106613328 @default.
• W2124460002 cites W2111246843 @default.
• W2124460002 cites W2111648036 @default.
• W2124460002 cites W2112024733 @default.
• W2124460002 cites W2113424916 @default.
• W2124460002 cites W2123371309 @default.
• W2124460002 cites W2123416046 @default.
• W2124460002 cites W2124208477 @default.
• W2124460002 cites W2125857619 @default.
• W2124460002 cites W2128570031 @default.
• W2124460002 cites W2130957039 @default.
• W2124460002 cites W2133846768 @default.
• W2124460002 cites W2140727482 @default.
• W2124460002 cites W2140886368 @default.
• W2124460002 cites W2140967957 @default.
• W2124460002 cites W2142170170 @default.
• W2124460002 cites W2142343162 @default.
• W2124460002 cites W2150073376 @default.
• W2124460002 cites W2158574701 @default.
• W2124460002 cites W2160378850 @default.
• W2124460002 cites W2160528385 @default.
• W2124460002 cites W2169140835 @default.
• W2124460002 cites W2170952050 @default.
• W2124460002 cites W2334504547 @default.
• W2124460002 cites W334309946 @default.
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• W2124460002 doi "https://doi.org/10.1186/1471-2164-9-397" @default.
• W2124460002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2547859" @default.
• W2124460002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18721461" @default.
• W2124460002 hasPublicationYear "2008" @default.
• W2124460002 type Work @default.
• W2124460002 sameAs 2124460002 @default.

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