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- W2124467771 abstract "Transient Receptor Potential (TRP) cation channels participate in various fundamental processes in cell- and organism-physiology in unicellular eukaryotes, invertebrates and vertebrates. Interestingly, many TRP channels function as detectors of sensory stimuli. The TRPV1 (vanilloid 1) channel serves as an integrator of noxious chemical and physical stimuli known to cause irritation and pain, such as elevated temperatures, acids, and irritant chemical compounds, and its activation has been linked to acute nociceptive pain and neurogenic inflammation. The mechanisms by which the channel detects incoming stimuli, how the sensing domains are coupled to channel gating and how these processes are connected to specific structural regions in the channel are not fully understood, but valuable information is available. Many sites in- volved in agonist detection have been characterized and gating models that describe many features of the channel's behav- ior have been put forward. Structural and functional information indicates TRP channels are similar to voltage-activated potassium channels, with a tetrameric organization and six-transmembrane-region subunits, a pore domain with multi-ion binding properties and an intracellular S6 gate that seems to be the point of convergence of the many activation modalities leading to the opening of the ion conduction pathway. Furthermore, TRPV1 expression is altered in various disease states and TRPV1 gene polymorphism was speculated to play a role in pain sensation. The complex activation and regulation of TRPV1 may have important implications for drug development." @default.
- W2124467771 created "2016-06-24" @default.
- W2124467771 creator A5024966374 @default.
- W2124467771 creator A5034492777 @default.
- W2124467771 creator A5073311910 @default.
- W2124467771 creator A5075622871 @default.
- W2124467771 creator A5081101560 @default.
- W2124467771 date "2010-01-01" @default.
- W2124467771 modified "2023-10-17" @default.
- W2124467771 title "Molecular Mechanisms of TRPV1 Channel Activation" @default.
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