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- W2124469250 endingPage "152" @default.
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- W2124469250 abstract "2-Bromo-4-fluoroaniline (1) was condensed with ethyl 2-cyano-3-ethoxyacrylate (2) in ethanol to afford 3, which upon refluxing in paraffin oil at 250°C gave 8-bromo-3-cyano-6-fluoroquinoline-4(1H)-one (4). Then, compound 4 was taken as a versatile building block that allows the synthesis of thieno[3,2-c]quinoline, pyrrolo[3,2-c]quinoline, and N-methylpyrrolo[3,2-c]quinoline systems. The newly synthesized compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR, 1H NMR, 13C NMR, and mass). Furthermore, some of these synthesized compounds were screened for their biological activities against various pathogenic bacterial and fungal strains. Our results demonstrate that most of the synthesized compounds possess a significant broad antibacterial activity against all strains of both gram-positive and gram-negative bacteria. In addition, compound 5 showed remarkable antifungal activity." @default.
- W2124469250 created "2016-06-24" @default.
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- W2124469250 date "2013-12-30" @default.
- W2124469250 modified "2023-10-14" @default.
- W2124469250 title "Synthesis, Reactions, and Biological Activities of Some New Thieno[3,2-<i>c</i>]quinoline and Pyrrolo[3,2-<i>c</i>]quinoline Derivatives" @default.
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- W2124469250 doi "https://doi.org/10.1002/ardp.201300167" @default.
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