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- W2124476971 abstract "Methods to confirm morphine in urine require hydrolysis to liberate morphine from its 3-beta-D glucuronide (M-3G) conjugate. Lengthy enzyme hydrolysis procedures prolong testing turnaround time whereas rapid enzyme methods may produce a low conversion of M-3G to morphine. The purpose of this study was to evaluate the quantitative conversion of M-3G to morphine in human urine using a thermally stable beta-glucuronidase isolated from Patella vulgata; to compare these findings with those obtained from acid hydrolysis; and to compare between-run imprecision for both hydrolysis methods. We found both enzyme and acid hydrolysis techniques to be efficient, giving 90.4% and 92.8% conversion of M-3G to morphine, respectively. Also, both methods were found to be reproducible. Over a 14 week period, 20 opiate confirmation batches were analyzed by each hydrolysis method; the coefficient of variation for morphine liberated from M-3G was 5.5% for enzyme hydrolysis and 2.7% for acid hydrolysis." @default.
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- W2124476971 date "1993-07-01" @default.
- W2124476971 modified "2023-10-14" @default.
- W2124476971 title "The Quantitative Conversion of Morphine 3-β-d Glucuronide to Morphine Using β-Glucuronidase Obtained from Patella vulgata as Compared to Acid Hydrolysis" @default.
- W2124476971 cites W105518027 @default.
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- W2124476971 doi "https://doi.org/10.1093/jat/17.4.208" @default.
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