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- W2124493135 abstract "In metazoans the endoplasmic reticulum (ER) changes during the cell cycle, with the nuclear envelope (NE) disassembling and reassembling during mitosis and the peripheral ER undergoing extensive remodeling. Here we address how ER morphology is generated during the cell cycle using crude and fractionated Xenopus laevis egg extracts. We show that in interphase the ER is concentrated at the microtubule (MT)-organizing center by dynein and is spread by outward extension of ER tubules through their association with plus ends of growing MTs. Fusion of membranes into an ER network is dependent on the guanosine triphosphatase atlastin (ATL). NE assembly requires fusion by both ATL and ER-soluble N-ethyl-maleimide-sensitive factor adaptor protein receptors. In mitotic extracts, the ER converts into a network of sheets connected by ER tubules and loses most of its interactions with MTs. Together, these results indicate that fusion of ER membranes by ATL and interaction of ER with growing MT ends and dynein cooperate to generate distinct ER morphologies during the cell cycle." @default.
- W2124493135 created "2016-06-24" @default.
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- W2124493135 date "2013-12-02" @default.
- W2124493135 modified "2023-10-14" @default.
- W2124493135 title "Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts" @default.
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- W2124493135 doi "https://doi.org/10.1083/jcb.201308001" @default.
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