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- W2124532015 abstract "Recent histological and molecular characterization of cholangiocarcinoma (CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological features. Furthermore, different stem cell niches have been recently described in the liver and biliary tree, suggesting this as the basis of the heterogeneity of intrahepatic (IH)- and extrahepatic (EH)-CCAs, which are two largely different tumors from both biological and epidemiological points of view. The complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver tumors. These recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic, prognostic and, hopefully, therapeutic categories of IH- and EH-CCAs." @default.
- W2124532015 created "2016-06-24" @default.
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- W2124532015 date "2012-01-01" @default.
- W2124532015 modified "2023-10-18" @default.
- W2124532015 title "Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity" @default.
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- W2124532015 doi "https://doi.org/10.4251/wjgo.v4.i5.94" @default.
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