FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124538861> ?p ?o ?g. }

• W2124538861 endingPage "1754" @default.
• W2124538861 startingPage "1749" @default.
• W2124538861 abstract "The polygenic nature of complex psychiatric disorders suggests a common pathway that may be involved in the down-regulation of multiple genes through an epigenetic mechanism. To investigate the role of methylation in down-regulating the expression of mRNAs that may be associated with the schizophrenia phenotype, we have adopted a cell-culture model amenable to this line of investigation. We have administered methionine (2 mM) to primary cultures of cortical neurons prepared from embryonic day 16 mice and show that this treatment down-regulated reelin and glutamic acid decarboxylase 67 (GAD67) mRNA expression but not that corresponding to neuron-specific enolase mRNA. Moreover, methionine increased methylation of the reelin promoter, suggesting a possible mechanism for the observed change. These cultures contain a mixed population of neurons and glia. Approximately 83% of the neurons are GABAergic based on GAD immunoreactivity, and these neurons coexpress high levels of reelin and DNA methyltransferase (Dnmt) 1 immunoreactivity. To examine whether Dnmt1 regulates reelin gene expression, we used an antisense approach to reduce (knock down) Dnmt1 expression. The reduced Dnmt1 mRNA and protein were accompanied by increased reelin mRNA expression. More importantly, the Dnmt1 knockdown blocked the methionine-induced reelin and GAD67 mRNA down-regulation. These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters." @default.
• W2124538861 created "2016-06-24" @default.
• W2124538861 creator A5005864766 @default.
• W2124538861 creator A5020088294 @default.
• W2124538861 creator A5039884481 @default.
• W2124538861 creator A5048825104 @default.
• W2124538861 creator A5049962686 @default.
• W2124538861 creator A5050677558 @default.
• W2124538861 creator A5051515082 @default.
• W2124538861 creator A5075306037 @default.
• W2124538861 creator A5080017287 @default.
• W2124538861 date "2005-01-25" @default.
• W2124538861 modified "2023-09-28" @default.
• W2124538861 title "DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures" @default.
• W2124538861 cites W1968700646 @default.
• W2124538861 cites W1971334707 @default.
• W2124538861 cites W1973118113 @default.
• W2124538861 cites W1979219206 @default.
• W2124538861 cites W1988486070 @default.
• W2124538861 cites W1991965466 @default.
• W2124538861 cites W1992764788 @default.
• W2124538861 cites W2001482790 @default.
• W2124538861 cites W2004119054 @default.
• W2124538861 cites W2004881650 @default.
• W2124538861 cites W2010629311 @default.
• W2124538861 cites W2013378746 @default.
• W2124538861 cites W2024913433 @default.
• W2124538861 cites W2027766570 @default.
• W2124538861 cites W2030718949 @default.
• W2124538861 cites W2046108122 @default.
• W2124538861 cites W2047886591 @default.
• W2124538861 cites W2048238454 @default.
• W2124538861 cites W2056372896 @default.
• W2124538861 cites W2057397032 @default.
• W2124538861 cites W2059097951 @default.
• W2124538861 cites W2059591675 @default.
• W2124538861 cites W2077363980 @default.
• W2124538861 cites W2091414779 @default.
• W2124538861 cites W2093187220 @default.
• W2124538861 cites W2095605218 @default.
• W2124538861 cites W2106622947 @default.
• W2124538861 cites W2107515797 @default.
• W2124538861 cites W2134450913 @default.
• W2124538861 cites W2137296349 @default.
• W2124538861 cites W2146264275 @default.
• W2124538861 cites W2156026059 @default.
• W2124538861 cites W2156305088 @default.
• W2124538861 cites W2161378898 @default.
• W2124538861 cites W2169759040 @default.
• W2124538861 cites W2170696995 @default.
• W2124538861 cites W2320983896 @default.
• W2124538861 cites W4367011184 @default.
• W2124538861 cites W2031003536 @default.
• W2124538861 doi "https://doi.org/10.1073/pnas.0409648102" @default.
• W2124538861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/547890" @default.
• W2124538861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15671176" @default.
• W2124538861 hasPublicationYear "2005" @default.
• W2124538861 type Work @default.
• W2124538861 sameAs 2124538861 @default.
• W2124538861 citedByCount "127" @default.
• W2124538861 countsByYear W21245388612012 @default.
• W2124538861 countsByYear W21245388612013 @default.
• W2124538861 countsByYear W21245388612014 @default.
• W2124538861 countsByYear W21245388612015 @default.
• W2124538861 countsByYear W21245388612016 @default.
• W2124538861 countsByYear W21245388612017 @default.
• W2124538861 countsByYear W21245388612018 @default.
• W2124538861 countsByYear W21245388612019 @default.
• W2124538861 countsByYear W21245388612020 @default.
• W2124538861 countsByYear W21245388612021 @default.
• W2124538861 countsByYear W21245388612022 @default.
• W2124538861 countsByYear W21245388612023 @default.
• W2124538861 crossrefType "journal-article" @default.
• W2124538861 hasAuthorship W2124538861A5005864766 @default.
• W2124538861 hasAuthorship W2124538861A5020088294 @default.
• W2124538861 hasAuthorship W2124538861A5039884481 @default.
• W2124538861 hasAuthorship W2124538861A5048825104 @default.
• W2124538861 hasAuthorship W2124538861A5049962686 @default.
• W2124538861 hasAuthorship W2124538861A5050677558 @default.
• W2124538861 hasAuthorship W2124538861A5051515082 @default.
• W2124538861 hasAuthorship W2124538861A5075306037 @default.
• W2124538861 hasAuthorship W2124538861A5080017287 @default.
• W2124538861 hasBestOaLocation W21245388611 @default.
• W2124538861 hasConcept C104317684 @default.
• W2124538861 hasConcept C105580179 @default.
• W2124538861 hasConcept C150194340 @default.
• W2124538861 hasConcept C153911025 @default.
• W2124538861 hasConcept C173396325 @default.
• W2124538861 hasConcept C175211621 @default.
• W2124538861 hasConcept C181199279 @default.
• W2124538861 hasConcept C189165786 @default.
• W2124538861 hasConcept C190727270 @default.
• W2124538861 hasConcept C2778063154 @default.
• W2124538861 hasConcept C2779979206 @default.
• W2124538861 hasConcept C33288867 @default.
• W2124538861 hasConcept C54355233 @default.
• W2124538861 hasConcept C55493867 @default.
• W2124538861 hasConcept C86803240 @default.

• next