FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124553275> ?p ?o ?g. }

• W2124553275 endingPage "1166" @default.
• W2124553275 startingPage "1159" @default.
• W2124553275 abstract "Glial fibrillary acidic protein (GFAP) is an established indicator of retinal stress; its expression in retinal astrocytes and Müller cells has been demonstrated to be modulated by cytokines and retinal pathology, including age related macular degeneration (AMD). This study aims to quantify the modulation of GFAP expression in retinas with drusen and atrophic AMD versus normal age matched controls.Following a histopathological survey, 17 donor retinas were classified into four groups: drusen (n=5), geographic atrophy (GA) (n=6), aged normal (n=3), and young normal (n=3). Paramacular cryosections were immunolabelled with GFAP antibody, examined by confocal microscopy, and quantified by NIH digital image analysis. Groups were matched for potential confounding factors including age, sex, and postmortem delay.A significant increase in GFAP immunolabelling of macroglia was noted in aged normal compared with young normal retinas (p<0.04). Upregulation of GFAP immunoreactivity involving astrocytes was observed in drusen retinas compared with control retinas (p<0.03). GFAP was also upregulated in retinas with GA compared with controls (p<0.05) and in retinas with GA compared with drusen (p<0.04), both involving Müller cells. Discrete regions of GFAP upregulation in Müller cells were associated with drusen formation. In GA specimens atrophied retinal pigment epithelium (RPE) was substituted by GFAP immunoreactive Müller cell processes (gliosis).This study provides a quantitative assessment of GFAP modulation in ageing and AMD affected retinas. Morphological observations were consistent with quantitative analyses indicating differential modulation of GFAP immunoreactivity in inner and outer retina. Upmodulation of GFAP in inner retina and astroglial processes was predominantly associated with drusen, while in outer retina Müller glia upmodulation of GFAP was associated with disruption of the RPE and blood-retinal barrier." @default.
• W2124553275 created "2016-06-24" @default.
• W2124553275 creator A5064074866 @default.
• W2124553275 date "2003-09-01" @default.
• W2124553275 modified "2023-10-14" @default.
• W2124553275 title "Differential expression of GFAP in early v late AMD: a quantitative analysis" @default.
• W2124553275 cites W1488124756 @default.
• W2124553275 cites W1522579454 @default.
• W2124553275 cites W1526448477 @default.
• W2124553275 cites W1582738275 @default.
• W2124553275 cites W1895565798 @default.
• W2124553275 cites W1964119221 @default.
• W2124553275 cites W1966785179 @default.
• W2124553275 cites W1971528177 @default.
• W2124553275 cites W1974084948 @default.
• W2124553275 cites W1977702697 @default.
• W2124553275 cites W1978248133 @default.
• W2124553275 cites W1986531295 @default.
• W2124553275 cites W1994626566 @default.
• W2124553275 cites W1997136014 @default.
• W2124553275 cites W2002954589 @default.
• W2124553275 cites W2004135846 @default.
• W2124553275 cites W2017200573 @default.
• W2124553275 cites W2021338387 @default.
• W2124553275 cites W2024856870 @default.
• W2124553275 cites W2039004863 @default.
• W2124553275 cites W2049448622 @default.
• W2124553275 cites W2050634340 @default.
• W2124553275 cites W2066326071 @default.
• W2124553275 cites W2068069084 @default.
• W2124553275 cites W2069110097 @default.
• W2124553275 cites W2079957682 @default.
• W2124553275 cites W2092552840 @default.
• W2124553275 cites W2092816889 @default.
• W2124553275 cites W2096722608 @default.
• W2124553275 cites W2101941700 @default.
• W2124553275 cites W2104421967 @default.
• W2124553275 cites W2105947076 @default.
• W2124553275 cites W2112694631 @default.
• W2124553275 cites W2127338217 @default.
• W2124553275 cites W2127507482 @default.
• W2124553275 cites W2146262948 @default.
• W2124553275 cites W2147413399 @default.
• W2124553275 cites W2152353759 @default.
• W2124553275 cites W2153126147 @default.
• W2124553275 cites W2154135871 @default.
• W2124553275 cites W2168812485 @default.
• W2124553275 cites W2170934194 @default.
• W2124553275 cites W252701286 @default.
• W2124553275 cites W25541533 @default.
• W2124553275 cites W4244094502 @default.
• W2124553275 cites W4299544095 @default.
• W2124553275 cites W51641863 @default.
• W2124553275 cites W59369753 @default.
• W2124553275 doi "https://doi.org/10.1136/bjo.87.9.1159" @default.
• W2124553275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1771844" @default.
• W2124553275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12928288" @default.
• W2124553275 hasPublicationYear "2003" @default.
• W2124553275 type Work @default.
• W2124553275 sameAs 2124553275 @default.
• W2124553275 citedByCount "122" @default.
• W2124553275 countsByYear W21245532752012 @default.
• W2124553275 countsByYear W21245532752013 @default.
• W2124553275 countsByYear W21245532752014 @default.
• W2124553275 countsByYear W21245532752015 @default.
• W2124553275 countsByYear W21245532752016 @default.
• W2124553275 countsByYear W21245532752017 @default.
• W2124553275 countsByYear W21245532752018 @default.
• W2124553275 countsByYear W21245532752019 @default.
• W2124553275 countsByYear W21245532752020 @default.
• W2124553275 countsByYear W21245532752021 @default.
• W2124553275 countsByYear W21245532752022 @default.
• W2124553275 countsByYear W21245532752023 @default.
• W2124553275 crossrefType "journal-article" @default.
• W2124553275 hasAuthorship W2124553275A5064074866 @default.
• W2124553275 hasBestOaLocation W21245532751 @default.
• W2124553275 hasConcept C118487528 @default.
• W2124553275 hasConcept C134018914 @default.
• W2124553275 hasConcept C142724271 @default.
• W2124553275 hasConcept C169760540 @default.
• W2124553275 hasConcept C204232928 @default.
• W2124553275 hasConcept C2776403814 @default.
• W2124553275 hasConcept C2777093970 @default.
• W2124553275 hasConcept C2777682930 @default.
• W2124553275 hasConcept C2778024200 @default.
• W2124553275 hasConcept C2778313320 @default.
• W2124553275 hasConcept C2779093074 @default.
• W2124553275 hasConcept C2780495277 @default.
• W2124553275 hasConcept C2780827179 @default.
• W2124553275 hasConcept C555293320 @default.
• W2124553275 hasConcept C71924100 @default.
• W2124553275 hasConcept C86803240 @default.
• W2124553275 hasConceptScore W2124553275C118487528 @default.
• W2124553275 hasConceptScore W2124553275C134018914 @default.
• W2124553275 hasConceptScore W2124553275C142724271 @default.
• W2124553275 hasConceptScore W2124553275C169760540 @default.
• W2124553275 hasConceptScore W2124553275C204232928 @default.
• W2124553275 hasConceptScore W2124553275C2776403814 @default.

• next