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- W2124562171 abstract "<h3>OBJECTIVES</h3> To determine the feasibility of monitoring the serum concentration of N<sup>G</sup>-hydroxy-l-arginine (l-NHA) as an index of an increased nitric oxide (NO) synthase activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) compared with nitrate (NO<sub>3</sub><sup>−</sup>), the major circulating metabolite of NO whose concentration is influenced by dietary intake. <h3>METHODS</h3> The serum concentrations ofl-NHA, l-arginine (l-Arg), and NO<sub>3</sub><sup>−</sup> were determined in 33 patients with RA, 25 patients with SLE and, 29 healthy subjects. <h3>RESULTS</h3> Serum l-NHA was significantly increased in RA patients with high disease activity (287% of control, p<0.01), but not with low disease activity (115%), as well as in patients with SLE (173%, p<0.01). In contrast, serum NO<sub>3</sub><sup>−</sup> did not differ significantly between either group of patients and the respective control group. <h3>CONCLUSION</h3> NO synthase activity or expression, or both, is upregulated in RA patients with high disease activity and in patients with SLE. Serum l-NHA seems to be a more specific and reliable index of an increased activity of this enzyme in patients with acute or chronic inflammatory diseases than NO<sub>3</sub><sup>−</sup>." @default.
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- W2124562171 title "Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity" @default.
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- W2124562171 doi "https://doi.org/10.1136/ard.56.5.330" @default.
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