FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124564248> ?p ?o ?g. }

• W2124564248 endingPage "8780" @default.
• W2124564248 startingPage "8770" @default.
• W2124564248 abstract "A region encompassing the rat aldolase B gene (aldB) promoter acts as a chromosomal origin of DNA replication (origin) in rat aldolase B-nonexpressing hepatoma cells. To examine replicator function of the aldB origin, we constructed recombinant mouse cell lines in which the rat aldB origin and the mutant derivatives were inserted into the same position at the mouse chromosome 8 by cre-mediated recombination. Nascent strand abundance assays revealed that the rat origin acts as a replicator at the ectopic mouse locus. Mutation of site C in the rat origin, which binds an Orc1-binding protein AlF-C in vitro, resulted in a significant reduction of the replicator activity in the mouse cells. Chromatin immunoprecipitation (ChIP) assays indicated that the reduction of replicator activity was paralleled with the reduced binding of AlF-C and Orc1, suggesting that sequence-specific binding of AlF-C to the ectopic rat origin leads to enhanced replicator activity in cooperation with Orc1. Involvement of AlF-C in replication in vivo was further examined for the aldB origin at its original rat locus and for a different rat origin identified in the present study, which contained an AlF-C-binding site. ChIP assays revealed that both replication origins bind AlF-C and Orc1. We think that the results presented here may represent one mode of origin recognition in mammalian cells." @default.
• W2124564248 created "2016-06-24" @default.
• W2124564248 creator A5001203533 @default.
• W2124564248 creator A5006840501 @default.
• W2124564248 creator A5036848186 @default.
• W2124564248 creator A5057346276 @default.
• W2124564248 creator A5080095660 @default.
• W2124564248 date "2006-12-01" @default.
• W2124564248 modified "2023-10-18" @default.
• W2124564248 title "Binding of AlF-C, an Orc1-Binding Transcriptional Regulator, Enhances Replicator Activity of the Rat Aldolase B Origin" @default.
• W2124564248 cites W1975739206 @default.
• W2124564248 cites W1982121118 @default.
• W2124564248 cites W1993623149 @default.
• W2124564248 cites W1998634853 @default.
• W2124564248 cites W1999306319 @default.
• W2124564248 cites W2003799938 @default.
• W2124564248 cites W2005962907 @default.
• W2124564248 cites W2006193637 @default.
• W2124564248 cites W2008486131 @default.
• W2124564248 cites W2008734588 @default.
• W2124564248 cites W2020024953 @default.
• W2124564248 cites W2029629276 @default.
• W2124564248 cites W2033349546 @default.
• W2124564248 cites W2036008069 @default.
• W2124564248 cites W2037632104 @default.
• W2124564248 cites W2041246826 @default.
• W2124564248 cites W2044651119 @default.
• W2124564248 cites W2045327902 @default.
• W2124564248 cites W2048036743 @default.
• W2124564248 cites W2050796617 @default.
• W2124564248 cites W2052381578 @default.
• W2124564248 cites W2056035211 @default.
• W2124564248 cites W2061481911 @default.
• W2124564248 cites W2064234837 @default.
• W2124564248 cites W2076091442 @default.
• W2124564248 cites W2077669160 @default.
• W2124564248 cites W2078682316 @default.
• W2124564248 cites W2084065100 @default.
• W2124564248 cites W2087909839 @default.
• W2124564248 cites W2091154116 @default.
• W2124564248 cites W2094898195 @default.
• W2124564248 cites W2097917015 @default.
• W2124564248 cites W2099117602 @default.
• W2124564248 cites W2102056802 @default.
• W2124564248 cites W2102964582 @default.
• W2124564248 cites W2103378958 @default.
• W2124564248 cites W2104190830 @default.
• W2124564248 cites W2106130068 @default.
• W2124564248 cites W2114342381 @default.
• W2124564248 cites W2127462380 @default.
• W2124564248 cites W2129320496 @default.
• W2124564248 cites W2134716960 @default.
• W2124564248 cites W2134870735 @default.
• W2124564248 cites W2137690299 @default.
• W2124564248 cites W2139509558 @default.
• W2124564248 cites W2140418170 @default.
• W2124564248 cites W2142416070 @default.
• W2124564248 cites W2142611898 @default.
• W2124564248 cites W2148055023 @default.
• W2124564248 cites W2149326681 @default.
• W2124564248 cites W2150658960 @default.
• W2124564248 cites W2157479857 @default.
• W2124564248 cites W2157614290 @default.
• W2124564248 cites W2160449667 @default.
• W2124564248 cites W2161218950 @default.
• W2124564248 cites W2165372706 @default.
• W2124564248 cites W2171742268 @default.
• W2124564248 doi "https://doi.org/10.1128/mcb.00949-06" @default.
• W2124564248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1636824" @default.
• W2124564248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16982680" @default.
• W2124564248 hasPublicationYear "2006" @default.
• W2124564248 type Work @default.
• W2124564248 sameAs 2124564248 @default.
• W2124564248 citedByCount "25" @default.
• W2124564248 countsByYear W21245642482012 @default.
• W2124564248 countsByYear W21245642482013 @default.
• W2124564248 countsByYear W21245642482014 @default.
• W2124564248 countsByYear W21245642482015 @default.
• W2124564248 countsByYear W21245642482023 @default.
• W2124564248 crossrefType "journal-article" @default.
• W2124564248 hasAuthorship W2124564248A5001203533 @default.
• W2124564248 hasAuthorship W2124564248A5006840501 @default.
• W2124564248 hasAuthorship W2124564248A5036848186 @default.
• W2124564248 hasAuthorship W2124564248A5057346276 @default.
• W2124564248 hasAuthorship W2124564248A5080095660 @default.
• W2124564248 hasBestOaLocation W21245642481 @default.
• W2124564248 hasConcept C101762097 @default.
• W2124564248 hasConcept C104317684 @default.
• W2124564248 hasConcept C104690221 @default.
• W2124564248 hasConcept C134320426 @default.
• W2124564248 hasConcept C150194340 @default.
• W2124564248 hasConcept C151158763 @default.
• W2124564248 hasConcept C153911025 @default.
• W2124564248 hasConcept C181199279 @default.
• W2124564248 hasConcept C188036394 @default.
• W2124564248 hasConcept C28165981 @default.
• W2124564248 hasConcept C54355233 @default.
• W2124564248 hasConcept C552990157 @default.

• next