FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124572912> ?p ?o ?g. }

• W2124572912 endingPage "472" @default.
• W2124572912 startingPage "467" @default.
• W2124572912 abstract "The effects of MgCl2 on the binding of tritiated ligands to opioid binding sites in homogenates of guinea-pig brain in HEPES buffer have been studied. The binding of tritiated mu-, delta-, and kappa-opioid agonists was promoted in a concentration-dependent manner over a range of MgCl2 concentrations from 0.1 mM to 10 mM, as was binding of the nonselective antagonists [3H]diprenorphine and [3H]naloxone. At concentrations of MgCl2 above 10 mM reversal of this effect was observed. The effects of MgCl2 on binding parameters differed at each site. The promoting effects of MgCl2 were mimicked by MnCl2, CaCl2, and MgSO4, but CoCl2 and ZnCl2 were inhibitory. Following treatment of guinea-pig brain synaptosomes at pH 11.5 to eliminate G proteins, the binding of the mu-opioid agonist [3H][D-Ala2, MePhe4, Gly-ol5]enkephalin and [3H]naloxone was much reduced but binding of [3H]diprenorphine was unaffected. Under these conditions MgCl2 still promoted binding of [3H]diprenorphine. The results suggest that Mg2+ ions promote binding by an action at the opioid receptor, even in the absence of G protein, and that opioid antagonists may differ in their recognition of opioid receptor binding sites." @default.
• W2124572912 created "2016-06-24" @default.
• W2124572912 creator A5022375777 @default.
• W2124572912 creator A5039205765 @default.
• W2124572912 creator A5069430108 @default.
• W2124572912 date "1992-08-01" @default.
• W2124572912 modified "2023-09-23" @default.
• W2124572912 title "Differential Effects of Mg²⁺and Other Divalent Cations on the Binding of Tritiated Opioid Ligands" @default.
• W2124572912 cites W159198934 @default.
• W2124572912 cites W1775749144 @default.
• W2124572912 cites W1964191104 @default.
• W2124572912 cites W1965501082 @default.
• W2124572912 cites W1972342582 @default.
• W2124572912 cites W1980596504 @default.
• W2124572912 cites W1984265477 @default.
• W2124572912 cites W1997891738 @default.
• W2124572912 cites W2013004435 @default.
• W2124572912 cites W2021514429 @default.
• W2124572912 cites W2023620032 @default.
• W2124572912 cites W2028141658 @default.
• W2124572912 cites W2032248898 @default.
• W2124572912 cites W2053387821 @default.
• W2124572912 cites W2063483021 @default.
• W2124572912 cites W2066579695 @default.
• W2124572912 cites W2076110518 @default.
• W2124572912 cites W2080875376 @default.
• W2124572912 cites W2080930955 @default.
• W2124572912 cites W2082213708 @default.
• W2124572912 cites W2082339044 @default.
• W2124572912 cites W2090383498 @default.
• W2124572912 cites W2125152850 @default.
• W2124572912 cites W2135890351 @default.
• W2124572912 cites W2144313499 @default.
• W2124572912 cites W2148947759 @default.
• W2124572912 cites W2412233475 @default.
• W2124572912 cites W4230517268 @default.
• W2124572912 cites W4301736084 @default.
• W2124572912 doi "https://doi.org/10.1111/j.1471-4159.1992.tb09393.x" @default.
• W2124572912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1321228" @default.
• W2124572912 hasPublicationYear "1992" @default.
• W2124572912 type Work @default.
• W2124572912 sameAs 2124572912 @default.
• W2124572912 citedByCount "36" @default.
• W2124572912 countsByYear W21245729122012 @default.
• W2124572912 countsByYear W21245729122014 @default.
• W2124572912 countsByYear W21245729122015 @default.
• W2124572912 countsByYear W21245729122016 @default.
• W2124572912 countsByYear W21245729122017 @default.
• W2124572912 countsByYear W21245729122018 @default.
• W2124572912 countsByYear W21245729122019 @default.
• W2124572912 countsByYear W21245729122020 @default.
• W2124572912 countsByYear W21245729122021 @default.
• W2124572912 countsByYear W21245729122022 @default.
• W2124572912 crossrefType "journal-article" @default.
• W2124572912 hasAuthorship W2124572912A5022375777 @default.
• W2124572912 hasAuthorship W2124572912A5039205765 @default.
• W2124572912 hasAuthorship W2124572912A5069430108 @default.
• W2124572912 hasConcept C107824862 @default.
• W2124572912 hasConcept C170493617 @default.
• W2124572912 hasConcept C178790620 @default.
• W2124572912 hasConcept C185592680 @default.
• W2124572912 hasConcept C2777803847 @default.
• W2124572912 hasConcept C2778750930 @default.
• W2124572912 hasConcept C2778938600 @default.
• W2124572912 hasConcept C2779012664 @default.
• W2124572912 hasConcept C2779886867 @default.
• W2124572912 hasConcept C2781063702 @default.
• W2124572912 hasConcept C55493867 @default.
• W2124572912 hasConcept C71240020 @default.
• W2124572912 hasConcept C74884574 @default.
• W2124572912 hasConceptScore W2124572912C107824862 @default.
• W2124572912 hasConceptScore W2124572912C170493617 @default.
• W2124572912 hasConceptScore W2124572912C178790620 @default.
• W2124572912 hasConceptScore W2124572912C185592680 @default.
• W2124572912 hasConceptScore W2124572912C2777803847 @default.
• W2124572912 hasConceptScore W2124572912C2778750930 @default.
• W2124572912 hasConceptScore W2124572912C2778938600 @default.
• W2124572912 hasConceptScore W2124572912C2779012664 @default.
• W2124572912 hasConceptScore W2124572912C2779886867 @default.
• W2124572912 hasConceptScore W2124572912C2781063702 @default.
• W2124572912 hasConceptScore W2124572912C55493867 @default.
• W2124572912 hasConceptScore W2124572912C71240020 @default.
• W2124572912 hasConceptScore W2124572912C74884574 @default.
• W2124572912 hasIssue "2" @default.
• W2124572912 hasLocation W21245729121 @default.
• W2124572912 hasLocation W21245729122 @default.
• W2124572912 hasOpenAccess W2124572912 @default.
• W2124572912 hasPrimaryLocation W21245729121 @default.
• W2124572912 hasRelatedWork W1782723841 @default.
• W2124572912 hasRelatedWork W1963976747 @default.
• W2124572912 hasRelatedWork W1982639372 @default.
• W2124572912 hasRelatedWork W1988344756 @default.
• W2124572912 hasRelatedWork W2076804236 @default.
• W2124572912 hasRelatedWork W2091330110 @default.
• W2124572912 hasRelatedWork W2124572912 @default.
• W2124572912 hasRelatedWork W2185982166 @default.
• W2124572912 hasRelatedWork W2441241457 @default.
• W2124572912 hasRelatedWork W3208824668 @default.

• next