FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124578045> ?p ?o ?g. }

• W2124578045 endingPage "629" @default.
• W2124578045 startingPage "624" @default.
• W2124578045 abstract "Pulmonary disease is the most important cause of morbidity and mortality in cystic fibrosis (CF). Most patients with CF die from respiratory failure with extensive airway destruction. Airway remodelling, defined as structural airway wall changes, begins early in life in CF but the sequence of remodelling events in the disease process is poorly understood. Airway remodelling in CF has traditionally been thought to be solely the consequence of repeated cycles of inflammation and infection. However, new evidence obtained from developmental, physiological and histopathological studies suggests that there might instead be multiple mechanisms leading to airway remodelling in CF including (1) changes related to infection and inflammation; (2) changes specific to CF as a result of CF transmembrane conductance regulator (CFTR) dysfunction in the airway wall, independent of infection and inflammation; and (3) protective responses to (1) and/or (2). Recent advances in bronchoscopic techniques have allowed airway mucosal (endobronchial) biopsies to be taken in children and even infants. Endobronchial biopsy studies may provide insight into the role and relative contribution of the different mechanisms of airway remodelling in CF, with the main limitation that they assess only changes in proximal large airways and not in peripheral small airways from where CF disease is thought to originate. Findings from biopsy studies could encourage the development of novel therapeutic strategies targeting structural changes in addition to infection and inflammation." @default.
• W2124578045 created "2016-06-24" @default.
• W2124578045 creator A5007986401 @default.
• W2124578045 creator A5062776492 @default.
• W2124578045 creator A5063471621 @default.
• W2124578045 creator A5063513802 @default.
• W2124578045 creator A5080982400 @default.
• W2124578045 date "2010-10-01" @default.
• W2124578045 modified "2023-10-18" @default.
• W2124578045 title "Airway remodelling and its relationship to inflammation in cystic fibrosis" @default.
• W2124578045 cites W1554379134 @default.
• W2124578045 cites W1845152202 @default.
• W2124578045 cites W1875993502 @default.
• W2124578045 cites W1983495472 @default.
• W2124578045 cites W1984917409 @default.
• W2124578045 cites W1989260226 @default.
• W2124578045 cites W1998354676 @default.
• W2124578045 cites W1999780808 @default.
• W2124578045 cites W2000006287 @default.
• W2124578045 cites W2000508966 @default.
• W2124578045 cites W2001118558 @default.
• W2124578045 cites W2013014565 @default.
• W2124578045 cites W2017634437 @default.
• W2124578045 cites W2032195196 @default.
• W2124578045 cites W2048363480 @default.
• W2124578045 cites W2060573195 @default.
• W2124578045 cites W2062211865 @default.
• W2124578045 cites W2063384774 @default.
• W2124578045 cites W2064143521 @default.
• W2124578045 cites W2065473309 @default.
• W2124578045 cites W2068994162 @default.
• W2124578045 cites W2075907160 @default.
• W2124578045 cites W2076280915 @default.
• W2124578045 cites W2085281894 @default.
• W2124578045 cites W2085376909 @default.
• W2124578045 cites W2088493680 @default.
• W2124578045 cites W2089259964 @default.
• W2124578045 cites W2090905532 @default.
• W2124578045 cites W2096242114 @default.
• W2124578045 cites W2110799130 @default.
• W2124578045 cites W2111878868 @default.
• W2124578045 cites W2112074177 @default.
• W2124578045 cites W2117249639 @default.
• W2124578045 cites W2119916715 @default.
• W2124578045 cites W2121804667 @default.
• W2124578045 cites W2122794095 @default.
• W2124578045 cites W2123398795 @default.
• W2124578045 cites W2125949575 @default.
• W2124578045 cites W2126470678 @default.
• W2124578045 cites W2130434435 @default.
• W2124578045 cites W2130622441 @default.
• W2124578045 cites W2131124203 @default.
• W2124578045 cites W2131770075 @default.
• W2124578045 cites W2133174706 @default.
• W2124578045 cites W2133233984 @default.
• W2124578045 cites W2134048775 @default.
• W2124578045 cites W2147054508 @default.
• W2124578045 cites W2148186686 @default.
• W2124578045 cites W2150355155 @default.
• W2124578045 cites W2166476126 @default.
• W2124578045 cites W2168424504 @default.
• W2124578045 cites W2171409767 @default.
• W2124578045 cites W2260250887 @default.
• W2124578045 cites W2395742741 @default.
• W2124578045 cites W3106798016 @default.
• W2124578045 cites W568728600 @default.
• W2124578045 cites W2522452060 @default.
• W2124578045 doi "https://doi.org/10.1136/thx.2009.134106" @default.
• W2124578045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20889525" @default.
• W2124578045 hasPublicationYear "2010" @default.
• W2124578045 type Work @default.
• W2124578045 sameAs 2124578045 @default.
• W2124578045 citedByCount "84" @default.
• W2124578045 countsByYear W21245780452012 @default.
• W2124578045 countsByYear W21245780452013 @default.
• W2124578045 countsByYear W21245780452014 @default.
• W2124578045 countsByYear W21245780452015 @default.
• W2124578045 countsByYear W21245780452016 @default.
• W2124578045 countsByYear W21245780452017 @default.
• W2124578045 countsByYear W21245780452018 @default.
• W2124578045 countsByYear W21245780452019 @default.
• W2124578045 countsByYear W21245780452020 @default.
• W2124578045 countsByYear W21245780452021 @default.
• W2124578045 countsByYear W21245780452022 @default.
• W2124578045 countsByYear W21245780452023 @default.
• W2124578045 crossrefType "journal-article" @default.
• W2124578045 hasAuthorship W2124578045A5007986401 @default.
• W2124578045 hasAuthorship W2124578045A5062776492 @default.
• W2124578045 hasAuthorship W2124578045A5063471621 @default.
• W2124578045 hasAuthorship W2124578045A5063513802 @default.
• W2124578045 hasAuthorship W2124578045A5080982400 @default.
• W2124578045 hasBestOaLocation W21245780451 @default.
• W2124578045 hasConcept C105922876 @default.
• W2124578045 hasConcept C126322002 @default.
• W2124578045 hasConcept C141071460 @default.
• W2124578045 hasConcept C142724271 @default.
• W2124578045 hasConcept C203014093 @default.
• W2124578045 hasConcept C2775934546 @default.

• next