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- W2124592370 abstract "In order to enhance DNA triple helix stability synthetic oligonucleotides have been developed that bear amino groups on the sugar or base. One of the most effective of these is bis-amino-U (B), which possesses 5-propargylamino and 2′-aminoethoxy modifications. Inclusion of this modified nucleotide not only greatly enhances triplex stability, but also increases the affinity for related sequences. We have used a restriction enzyme protection, selection and amplification assay (REPSA) to isolate sequences that are bound by the heavily modified 9-mer triplex-forming oligonucleotide B 6 CBT. The isolated sequences contain A n tracts ( n = 6), suggesting that the 5′-end of this TFO was responsible for successful triplex formation. DNase I footprinting with these sequences confirmed triple helix formation at these secondary targets and demonstrated no interaction with similar oligonucleotides containing T or 5-propargylamino-dU." @default.
- W2124592370 created "2016-06-24" @default.
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- W2124592370 date "2011-12-16" @default.
- W2124592370 modified "2023-10-18" @default.
- W2124592370 title "Secondary binding sites for heavily modified triplex forming oligonucleotides" @default.
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- W2124592370 doi "https://doi.org/10.1093/nar/gkr1119" @default.
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