FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124593766> ?p ?o ?g. }

• W2124593766 endingPage "891" @default.
• W2124593766 startingPage "884" @default.
• W2124593766 abstract "The factors behind the reemergence of severe, invasive group A streptococcal (GAS) diseases are unclear, but it could be caused by altered genetic endowment in these organisms. However, data from previous studies assessing the association between single genetic factors and invasive disease are often conflicting, suggesting that other, as-yet unidentified factors are necessary for the development of this class of disease.In this study, we used a targeted GAS virulence microarray containing 226 GAS genes to determine the virulence gene repertoires of 68 GAS isolates (42 associated with invasive disease and 28 associated with noninvasive disease) collected in a defined geographic location during a contiguous time period. We then employed 3 advanced machine learning methods (genetic algorithm neural network, support vector machines, and classification trees) to identify genes with an increased association with invasive disease.Virulence gene profiles of individual GAS isolates varied extensively among these geographically and temporally related strains. Using genetic algorithm neural network analysis, we identified 3 genes with a marginal overrepresentation in invasive disease isolates. Significantly, 2 of these genes, ssa and mf4, encoded superantigens but were only present in a restricted set of GAS M-types. The third gene, spa, was found in variable distributions in all M-types in the study.Our comprehensive analysis of GAS virulence profiles provides strong evidence for the incongruent relationships among any of the 226 genes represented on the array and the overall propensity of GAS to cause invasive disease, underscoring the pathogenic complexity of these diseases, as well as the importance of multiple bacteria and/or host factors." @default.
• W2124593766 created "2016-06-24" @default.
• W2124593766 creator A5011239554 @default.
• W2124593766 creator A5021247221 @default.
• W2124593766 creator A5031876902 @default.
• W2124593766 creator A5033027758 @default.
• W2124593766 creator A5060304095 @default.
• W2124593766 creator A5063083987 @default.
• W2124593766 creator A5068954911 @default.
• W2124593766 creator A5073850774 @default.
• W2124593766 creator A5074513028 @default.
• W2124593766 date "2006-10-01" @default.
• W2124593766 modified "2023-10-15" @default.
• W2124593766 title "Genes for the Majority Of Group A Streptococcal Virulence Factors and Extracellular Surface Proteins Do Not Confer an Increased Propensity to Cause Invasive Disease" @default.
• W2124593766 cites W1548409781 @default.
• W2124593766 cites W1819319716 @default.
• W2124593766 cites W1899896313 @default.
• W2124593766 cites W1905556451 @default.
• W2124593766 cites W1913344433 @default.
• W2124593766 cites W1980636080 @default.
• W2124593766 cites W1982028373 @default.
• W2124593766 cites W2001129735 @default.
• W2124593766 cites W2006081775 @default.
• W2124593766 cites W2009991902 @default.
• W2124593766 cites W2026771646 @default.
• W2124593766 cites W2035652411 @default.
• W2124593766 cites W2048008965 @default.
• W2124593766 cites W2050638908 @default.
• W2124593766 cites W2069535714 @default.
• W2124593766 cites W2070144977 @default.
• W2124593766 cites W2071114499 @default.
• W2124593766 cites W2073228865 @default.
• W2124593766 cites W2090879644 @default.
• W2124593766 cites W2104787607 @default.
• W2124593766 cites W2116235763 @default.
• W2124593766 cites W2117919289 @default.
• W2124593766 cites W2118733892 @default.
• W2124593766 cites W2123893523 @default.
• W2124593766 cites W2126719129 @default.
• W2124593766 cites W2136134669 @default.
• W2124593766 cites W2138529637 @default.
• W2124593766 cites W2141603364 @default.
• W2124593766 cites W2143426320 @default.
• W2124593766 cites W2150550043 @default.
• W2124593766 cites W2155467760 @default.
• W2124593766 cites W2170224762 @default.
• W2124593766 cites W2171091522 @default.
• W2124593766 cites W2171780167 @default.
• W2124593766 doi "https://doi.org/10.1086/507537" @default.
• W2124593766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16941370" @default.
• W2124593766 hasPublicationYear "2006" @default.
• W2124593766 type Work @default.
• W2124593766 sameAs 2124593766 @default.
• W2124593766 citedByCount "34" @default.
• W2124593766 countsByYear W21245937662012 @default.
• W2124593766 countsByYear W21245937662014 @default.
• W2124593766 countsByYear W21245937662016 @default.
• W2124593766 countsByYear W21245937662017 @default.
• W2124593766 countsByYear W21245937662018 @default.
• W2124593766 countsByYear W21245937662019 @default.
• W2124593766 countsByYear W21245937662020 @default.
• W2124593766 crossrefType "journal-article" @default.
• W2124593766 hasAuthorship W2124593766A5011239554 @default.
• W2124593766 hasAuthorship W2124593766A5021247221 @default.
• W2124593766 hasAuthorship W2124593766A5031876902 @default.
• W2124593766 hasAuthorship W2124593766A5033027758 @default.
• W2124593766 hasAuthorship W2124593766A5060304095 @default.
• W2124593766 hasAuthorship W2124593766A5063083987 @default.
• W2124593766 hasAuthorship W2124593766A5068954911 @default.
• W2124593766 hasAuthorship W2124593766A5073850774 @default.
• W2124593766 hasAuthorship W2124593766A5074513028 @default.
• W2124593766 hasBestOaLocation W21245937661 @default.
• W2124593766 hasConcept C104317684 @default.
• W2124593766 hasConcept C142724271 @default.
• W2124593766 hasConcept C2779134260 @default.
• W2124593766 hasConcept C54355233 @default.
• W2124593766 hasConcept C60987743 @default.
• W2124593766 hasConcept C68873052 @default.
• W2124593766 hasConcept C71924100 @default.
• W2124593766 hasConcept C86803240 @default.
• W2124593766 hasConceptScore W2124593766C104317684 @default.
• W2124593766 hasConceptScore W2124593766C142724271 @default.
• W2124593766 hasConceptScore W2124593766C2779134260 @default.
• W2124593766 hasConceptScore W2124593766C54355233 @default.
• W2124593766 hasConceptScore W2124593766C60987743 @default.
• W2124593766 hasConceptScore W2124593766C68873052 @default.
• W2124593766 hasConceptScore W2124593766C71924100 @default.
• W2124593766 hasConceptScore W2124593766C86803240 @default.
• W2124593766 hasIssue "7" @default.
• W2124593766 hasLocation W21245937661 @default.
• W2124593766 hasLocation W21245937662 @default.
• W2124593766 hasLocation W21245937663 @default.
• W2124593766 hasOpenAccess W2124593766 @default.
• W2124593766 hasPrimaryLocation W21245937661 @default.
• W2124593766 hasRelatedWork W1577012645 @default.
• W2124593766 hasRelatedWork W1972335439 @default.
• W2124593766 hasRelatedWork W1979172052 @default.
• W2124593766 hasRelatedWork W2034625591 @default.

• next