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• W2124622147 endingPage "2010" @default.
• W2124622147 startingPage "2001" @default.
• W2124622147 abstract "The anterior cruciate ligament (ACL) functions as a mechanical stabilizer in the tibiofemoral joint, and is the most commonly injured knee ligament. To improve the clinical outcome of tendon grafts used for ACL reconstructions, our long-term goal is to promote graft–bone integration via the regeneration of the native ligament–bone interface. An understanding of strain distribution at this interface is crucial for functional scaffold design and clinical evaluation. Experimental determination, however, has been difficult due to the small length scale of the insertion sites. This study utilizes ultrasound elastography to characterize the response of the ACL and ACL–bone interface under tension. Specifically, bovine tibiofemoral joints were mounted on a material testing system and loaded in tension while radiofrequency (RF) data were acquired at 5 MHz. Axial strain elastograms between RF frames and a reference frame were generated using crosscorrelation and recorrelation techniques. Elastographic analyses revealed that when the joint was loaded in tension, complex strains with both compressive and tensile components occurred at the tibial insertion, with higher strains found at the insertion sites. In addition, the displacement was greatest at the ACL proper and decreased in value gradually from ligament to bone, likely a reflection of the matrix organization at the ligament–bone interface. Our results indicate that elastography is a novel method that can be readily used to characterize the mechanical properties of the ACL and its insertions into bone. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:2001–2010, 2006" @default.
• W2124622147 created "2016-06-24" @default.
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• W2124622147 date "2006-01-01" @default.
• W2124622147 modified "2023-10-16" @default.
• W2124622147 title "Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament–bone insertions" @default.
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• W2124622147 doi "https://doi.org/10.1002/jor.20260" @default.
• W2124622147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16900541" @default.
• W2124622147 hasPublicationYear "2006" @default.
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