FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124646087> ?p ?o ?g. }

• W2124646087 endingPage "142" @default.
• W2124646087 startingPage "135" @default.
• W2124646087 abstract "Bisphosphonates (BP) are powerful inhibitors of bone resorption. Their mechanism of action, although still unclear, is now believed to be at the cellular level. In this study we investigated the effects of these compounds on proliferation, induced either by L-cell conditioned medium (CSF-1) or 4-phorbol 12-myristate 13-acetate (PMA) of bone marrow cells (BMC) and on CSF-1-induced proliferation and viability of bone marrow derived macrophages (BMDM phi). BMC proliferation, measured by [3H]-TdR incorporation or by clonal assay in soft agar, was significantly inhibited by 4-amino-1-hydroxybutylidene-1,1-bisphosphonate (AHBuBP) and 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (AHPrBP) at 2.5 x 10(-7) M and by dichloromethylenebisphosphonate (Cl2MBP) at 2.5 x 10(-6) M. This inhibitory effect was also confirmed on the proliferation, measured by [3H]-TdR incorporation, of BMDM phi. In the absence of CSF-1, the viability of this latter cell population, estimated by DNA content per well and lactate dehydrogenase (LDH) released into the medium, was affected in the following order of concentrations: Cl2MBP, 1.0 x 10(-4) M; AHBuBP, 5.0 x 10(-5) M; and AHPrBP, 2.5 x 10(-5) M. Since osteoclasts and macrophages might share a common early progenitor cell, probably under the control of CSF-1, the effect exerted by BP on the proliferation of the macrophage precursors may also be extended to the osteoclast precursors." @default.
• W2124646087 created "2016-06-24" @default.
• W2124646087 creator A5018378255 @default.
• W2124646087 creator A5037855886 @default.
• W2124646087 creator A5056793114 @default.
• W2124646087 creator A5084886246 @default.
• W2124646087 date "2009-12-03" @default.
• W2124646087 modified "2023-10-14" @default.
• W2124646087 title "Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages" @default.
• W2124646087 cites W1518732451 @default.
• W2124646087 cites W1586184805 @default.
• W2124646087 cites W1777681465 @default.
• W2124646087 cites W1940165732 @default.
• W2124646087 cites W1963841012 @default.
• W2124646087 cites W1963935558 @default.
• W2124646087 cites W1971712306 @default.
• W2124646087 cites W1981084939 @default.
• W2124646087 cites W1982748889 @default.
• W2124646087 cites W1994173359 @default.
• W2124646087 cites W1995181451 @default.
• W2124646087 cites W1998470807 @default.
• W2124646087 cites W1998490733 @default.
• W2124646087 cites W1999968337 @default.
• W2124646087 cites W2006953927 @default.
• W2124646087 cites W2007139416 @default.
• W2124646087 cites W2007386203 @default.
• W2124646087 cites W2009071266 @default.
• W2124646087 cites W2011881359 @default.
• W2124646087 cites W2013672165 @default.
• W2124646087 cites W2020039195 @default.
• W2124646087 cites W2020441862 @default.
• W2124646087 cites W2020593622 @default.
• W2124646087 cites W2025179576 @default.
• W2124646087 cites W2027378713 @default.
• W2124646087 cites W2028329951 @default.
• W2124646087 cites W2034117349 @default.
• W2124646087 cites W2034733431 @default.
• W2124646087 cites W2047307188 @default.
• W2124646087 cites W2053188759 @default.
• W2124646087 cites W2058788578 @default.
• W2124646087 cites W2066318392 @default.
• W2124646087 cites W2066694610 @default.
• W2124646087 cites W2080135613 @default.
• W2124646087 cites W2081588688 @default.
• W2124646087 cites W2083334726 @default.
• W2124646087 cites W2085881510 @default.
• W2124646087 cites W2089364695 @default.
• W2124646087 cites W2095985832 @default.
• W2124646087 cites W2140547471 @default.
• W2124646087 cites W2158226610 @default.
• W2124646087 cites W2337554251 @default.
• W2124646087 cites W2341018117 @default.
• W2124646087 cites W2395496929 @default.
• W2124646087 cites W2477752947 @default.
• W2124646087 cites W4322697268 @default.
• W2124646087 doi "https://doi.org/10.1002/jbmr.5650020209" @default.
• W2124646087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3455162" @default.
• W2124646087 hasPublicationYear "2009" @default.
• W2124646087 type Work @default.
• W2124646087 sameAs 2124646087 @default.
• W2124646087 citedByCount "134" @default.
• W2124646087 countsByYear W21246460872012 @default.
• W2124646087 countsByYear W21246460872013 @default.
• W2124646087 countsByYear W21246460872015 @default.
• W2124646087 countsByYear W21246460872016 @default.
• W2124646087 countsByYear W21246460872017 @default.
• W2124646087 countsByYear W21246460872018 @default.
• W2124646087 countsByYear W21246460872019 @default.
• W2124646087 countsByYear W21246460872020 @default.
• W2124646087 countsByYear W21246460872021 @default.
• W2124646087 countsByYear W21246460872023 @default.
• W2124646087 crossrefType "journal-article" @default.
• W2124646087 hasAuthorship W2124646087A5018378255 @default.
• W2124646087 hasAuthorship W2124646087A5037855886 @default.
• W2124646087 hasAuthorship W2124646087A5056793114 @default.
• W2124646087 hasAuthorship W2124646087A5084886246 @default.
• W2124646087 hasConcept C126322002 @default.
• W2124646087 hasConcept C134018914 @default.
• W2124646087 hasConcept C1491633281 @default.
• W2124646087 hasConcept C153911025 @default.
• W2124646087 hasConcept C181199279 @default.
• W2124646087 hasConcept C185592680 @default.
• W2124646087 hasConcept C201750760 @default.
• W2124646087 hasConcept C202751555 @default.
• W2124646087 hasConcept C2776033226 @default.
• W2124646087 hasConcept C2776541429 @default.
• W2124646087 hasConcept C2777251235 @default.
• W2124646087 hasConcept C2777318727 @default.
• W2124646087 hasConcept C2779244956 @default.
• W2124646087 hasConcept C2780007613 @default.
• W2124646087 hasConcept C28328180 @default.
• W2124646087 hasConcept C2908647359 @default.
• W2124646087 hasConcept C53227056 @default.
• W2124646087 hasConcept C55493867 @default.
• W2124646087 hasConcept C62112901 @default.
• W2124646087 hasConcept C64241487 @default.
• W2124646087 hasConcept C673006 @default.
• W2124646087 hasConcept C71924100 @default.

• next