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- W2124652267 abstract "Abstract The spatial organization of the genome within the eukaryotic nucleus is a dynamic process that plays a central role in cellular processes such as gene expression, DNA replication, and chromosome segregation. Condensins are conserved multi-subunit protein complexes that contribute to chromosome organization by regulating chromosome compaction and homolog pairing. Previous work in our laboratory has shown that the Cap-H2 subunit of condensin II physically and genetically interacts with the Drosophila homolog of human MORF4-related gene on chromosome 15 (MRG15). Like Cap-H2, Mrg15 is required for interphase chromosome compaction and homolog pairing. However, the mechanism by which Mrg15 and Cap-H2 cooperate to maintain interphase chromatin organization remains unclear. Here, we show that Cap-H2 localizes to interband regions on polytene chromosomes and co-localizes with Mrg15 at regions of active transcription across the genome. We show that co-localization of Cap-H2 on polytene chromosomes is partially dependent on Mrg15. We have identified a binding motif within Cap-H2 that is essential for its interaction with Mrg15, and have found that mutation of this motif results in loss of localization of Cap-H2 on polytene chromosomes and results in partial suppression of Cap-H2-mediated compaction and homolog unpairing. Our data are consistent with a model in which Mrg15 acts as a loading factor to facilitate Cap-H2 binding to chromatin and mediate changes in chromatin organization." @default.
- W2124652267 created "2016-06-24" @default.
- W2124652267 creator A5010883436 @default.
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- W2124652267 creator A5061515187 @default.
- W2124652267 creator A5074482257 @default.
- W2124652267 date "2015-05-01" @default.
- W2124652267 modified "2023-10-16" @default.
- W2124652267 title "Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2" @default.
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- W2124652267 doi "https://doi.org/10.1534/g3.115.016634" @default.
- W2124652267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4426367" @default.
- W2124652267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25758823" @default.
- W2124652267 hasPublicationYear "2015" @default.
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