FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124668830> ?p ?o ?g. }

• W2124668830 endingPage "e13095" @default.
• W2124668830 startingPage "e13095" @default.
• W2124668830 abstract "The proteasome inhibitor bortezomib represents an important advance in the treatment of multiple myeloma (MM). Bortezomib inhibits the activity of the 26S proteasome and induces cell death in a variety of tumor cells; however, the mechanism of cytotoxicity is not well understood.We investigated the differential phosphoproteome upon proteasome inhibition by using stable isotope labeling by amino acids in cell culture (SILAC) in combination with phosphoprotein enrichment and LC-MS/MS analysis. In total 233 phosphoproteins were identified and 72 phosphoproteins showed a 1.5-fold or greater change upon bortezomib treatment. The phosphoproteins with expression alterations encompass all major protein classes, including a large number of nucleic acid binding proteins. Site-specific phosphopeptide quantitation revealed that Ser38 phosphorylation on stathmin increased upon bortezomib treatment, suggesting new mechanisms associated to bortezomib-induced apoptosis in MM cells. Further studies demonstrated that stathmin phosphorylation profile was modified in response to bortezomib treatment and the regulation of stathmin by phosphorylation at specific Ser/Thr residues participated in the cellular response induced by bortezomib.Our systematic profiling of phosphorylation changes in response to bortezomib treatment not only advanced the global mechanistic understanding of the action of bortezomib on myeloma cells but also identified previously uncharacterized signaling proteins in myeloma cells." @default.
• W2124668830 created "2016-06-24" @default.
• W2124668830 creator A5003686868 @default.
• W2124668830 creator A5012921461 @default.
• W2124668830 creator A5029540163 @default.
• W2124668830 creator A5038259858 @default.
• W2124668830 creator A5041424937 @default.
• W2124668830 creator A5053810460 @default.
• W2124668830 creator A5054181370 @default.
• W2124668830 creator A5060394204 @default.
• W2124668830 creator A5071074966 @default.
• W2124668830 creator A5078887271 @default.
• W2124668830 date "2010-09-29" @default.
• W2124668830 modified "2023-10-14" @default.
• W2124668830 title "Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells" @default.
• W2124668830 cites W1495816485 @default.
• W2124668830 cites W1600462418 @default.
• W2124668830 cites W160478922 @default.
• W2124668830 cites W169449544 @default.
• W2124668830 cites W1975259111 @default.
• W2124668830 cites W1980471295 @default.
• W2124668830 cites W1982375470 @default.
• W2124668830 cites W1993218631 @default.
• W2124668830 cites W1993643129 @default.
• W2124668830 cites W1993643473 @default.
• W2124668830 cites W1994737830 @default.
• W2124668830 cites W1994823455 @default.
• W2124668830 cites W1995912930 @default.
• W2124668830 cites W2020995084 @default.
• W2124668830 cites W2024336151 @default.
• W2124668830 cites W2030381320 @default.
• W2124668830 cites W2033260840 @default.
• W2124668830 cites W2035894594 @default.
• W2124668830 cites W2037156284 @default.
• W2124668830 cites W2042325333 @default.
• W2124668830 cites W2043049816 @default.
• W2124668830 cites W2054118753 @default.
• W2124668830 cites W2055793916 @default.
• W2124668830 cites W2059337817 @default.
• W2124668830 cites W2074911710 @default.
• W2124668830 cites W2077731772 @default.
• W2124668830 cites W2085037886 @default.
• W2124668830 cites W2089944489 @default.
• W2124668830 cites W2089963166 @default.
• W2124668830 cites W2094186182 @default.
• W2124668830 cites W2095013827 @default.
• W2124668830 cites W2102714295 @default.
• W2124668830 cites W2104726963 @default.
• W2124668830 cites W2121011397 @default.
• W2124668830 cites W2123500593 @default.
• W2124668830 cites W2128987420 @default.
• W2124668830 cites W2131994406 @default.
• W2124668830 cites W2135252110 @default.
• W2124668830 cites W2135805255 @default.
• W2124668830 cites W2138102966 @default.
• W2124668830 cites W2140946052 @default.
• W2124668830 cites W2146502962 @default.
• W2124668830 cites W2146508102 @default.
• W2124668830 cites W2150099809 @default.
• W2124668830 cites W2150123812 @default.
• W2124668830 cites W2152065071 @default.
• W2124668830 cites W2152091753 @default.
• W2124668830 cites W2156320420 @default.
• W2124668830 cites W2158892689 @default.
• W2124668830 cites W2163591703 @default.
• W2124668830 cites W2166747788 @default.
• W2124668830 cites W2168691181 @default.
• W2124668830 cites W2170960877 @default.
• W2124668830 cites W2793216206 @default.
• W2124668830 cites W86393948 @default.
• W2124668830 doi "https://doi.org/10.1371/journal.pone.0013095" @default.
• W2124668830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2947515" @default.
• W2124668830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20927383" @default.
• W2124668830 hasPublicationYear "2010" @default.
• W2124668830 type Work @default.
• W2124668830 sameAs 2124668830 @default.
• W2124668830 citedByCount "28" @default.
• W2124668830 countsByYear W21246688302012 @default.
• W2124668830 countsByYear W21246688302013 @default.
• W2124668830 countsByYear W21246688302014 @default.
• W2124668830 countsByYear W21246688302015 @default.
• W2124668830 countsByYear W21246688302016 @default.
• W2124668830 countsByYear W21246688302017 @default.
• W2124668830 countsByYear W21246688302018 @default.
• W2124668830 countsByYear W21246688302019 @default.
• W2124668830 countsByYear W21246688302020 @default.
• W2124668830 countsByYear W21246688302021 @default.
• W2124668830 countsByYear W21246688302023 @default.
• W2124668830 crossrefType "journal-article" @default.
• W2124668830 hasAuthorship W2124668830A5003686868 @default.
• W2124668830 hasAuthorship W2124668830A5012921461 @default.
• W2124668830 hasAuthorship W2124668830A5029540163 @default.
• W2124668830 hasAuthorship W2124668830A5038259858 @default.
• W2124668830 hasAuthorship W2124668830A5041424937 @default.
• W2124668830 hasAuthorship W2124668830A5053810460 @default.
• W2124668830 hasAuthorship W2124668830A5054181370 @default.
• W2124668830 hasAuthorship W2124668830A5060394204 @default.
• W2124668830 hasAuthorship W2124668830A5071074966 @default.

• next