FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124672011> ?p ?o ?g. }

• W2124672011 endingPage "36" @default.
• W2124672011 startingPage "32" @default.
• W2124672011 abstract "Chromosome 1p deletions are common in advanced neuroblastomas, but the biological and clinical implications of this clonal rearrangement remain controversial. Previous studies of chromosome 1p loss of heterozygosity (LOH) have been limited by analyses of relatively small number of tumors derived from heterogeneously assessed and treated patient populations. Therefore, a strictly representative cohort of 288 Children's Cancer Group neuroblastoma patients treated on the most recent phase III therapeutic trials was identified.Primary tumors from these patients were analyzed for LOH at precisely mapped and highly informative 1p polymorphic loci located from 1p32 to 1p36.3 by multiplex PCR.Ninety-three primary tumor specimens (32%) had LOH at multiple 1p36 marker loci. All 1p deletions overlapped the previously determined smallest region of overlap (SRO). One tumor had a small terminal deletion completely within 1p36.3, allowing for further refinement of the 1p36 SRO. We found no evidence to support an additional, nonoverlapping region of LOH within 1p32-36. We confirmed the strong correlation of 1p36 LOH with MYCN amplification (P < 0.001), advanced disease stage (P < 0.001), and decreased both 3-year event-free survival and overall survival probabilities (P< 0.001). When stratified for MYCN amplification status or entered into a multivariate analysis, 1p36 LOH remained predictive for decreased event-free survival, but not overall survival probability.These data support the hypothesis that inactivation of a tumor suppressor gene within 1p36.3 is associated with an increased risk for disease relapse." @default.
• W2124672011 created "2016-06-24" @default.
• W2124672011 creator A5004950779 @default.
• W2124672011 creator A5005797590 @default.
• W2124672011 creator A5017840054 @default.
• W2124672011 creator A5021003209 @default.
• W2124672011 creator A5024659860 @default.
• W2124672011 creator A5038763858 @default.
• W2124672011 creator A5042503456 @default.
• W2124672011 creator A5044611916 @default.
• W2124672011 creator A5045426069 @default.
• W2124672011 creator A5046710077 @default.
• W2124672011 creator A5061302621 @default.
• W2124672011 creator A5067145358 @default.
• W2124672011 date "2001-01-01" @default.
• W2124672011 modified "2023-10-08" @default.
• W2124672011 title "Comprehensive analysis of chromosome 1p deletions in neuroblastoma" @default.
• W2124672011 cites W1926885922 @default.
• W2124672011 cites W1982698039 @default.
• W2124672011 cites W1982939999 @default.
• W2124672011 cites W1988766671 @default.
• W2124672011 cites W1994076841 @default.
• W2124672011 cites W2012219845 @default.
• W2124672011 cites W2016251173 @default.
• W2124672011 cites W2071059965 @default.
• W2124672011 cites W2081455238 @default.
• W2124672011 cites W2118351051 @default.
• W2124672011 cites W2132604294 @default.
• W2124672011 cites W2161396659 @default.
• W2124672011 cites W2168833587 @default.
• W2124672011 cites W947041447 @default.
• W2124672011 doi "https://doi.org/10.1002/1096-911x(20010101)36:1<32::aid-mpo1009>3.0.co;2-0" @default.
• W2124672011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11464900" @default.
• W2124672011 hasPublicationYear "2001" @default.
• W2124672011 type Work @default.
• W2124672011 sameAs 2124672011 @default.
• W2124672011 citedByCount "67" @default.
• W2124672011 countsByYear W21246720112012 @default.
• W2124672011 countsByYear W21246720112014 @default.
• W2124672011 countsByYear W21246720112015 @default.
• W2124672011 countsByYear W21246720112016 @default.
• W2124672011 countsByYear W21246720112017 @default.
• W2124672011 countsByYear W21246720112018 @default.
• W2124672011 countsByYear W21246720112019 @default.
• W2124672011 countsByYear W21246720112020 @default.
• W2124672011 countsByYear W21246720112021 @default.
• W2124672011 countsByYear W21246720112022 @default.
• W2124672011 countsByYear W21246720112023 @default.
• W2124672011 crossrefType "journal-article" @default.
• W2124672011 hasAuthorship W2124672011A5004950779 @default.
• W2124672011 hasAuthorship W2124672011A5005797590 @default.
• W2124672011 hasAuthorship W2124672011A5017840054 @default.
• W2124672011 hasAuthorship W2124672011A5021003209 @default.
• W2124672011 hasAuthorship W2124672011A5024659860 @default.
• W2124672011 hasAuthorship W2124672011A5038763858 @default.
• W2124672011 hasAuthorship W2124672011A5042503456 @default.
• W2124672011 hasAuthorship W2124672011A5044611916 @default.
• W2124672011 hasAuthorship W2124672011A5045426069 @default.
• W2124672011 hasAuthorship W2124672011A5046710077 @default.
• W2124672011 hasAuthorship W2124672011A5061302621 @default.
• W2124672011 hasAuthorship W2124672011A5067145358 @default.
• W2124672011 hasConcept C104317684 @default.
• W2124672011 hasConcept C120599132 @default.
• W2124672011 hasConcept C126322002 @default.
• W2124672011 hasConcept C143589142 @default.
• W2124672011 hasConcept C143998085 @default.
• W2124672011 hasConcept C180754005 @default.
• W2124672011 hasConcept C2776715637 @default.
• W2124672011 hasConcept C2778264664 @default.
• W2124672011 hasConcept C30481170 @default.
• W2124672011 hasConcept C36823959 @default.
• W2124672011 hasConcept C502942594 @default.
• W2124672011 hasConcept C54355233 @default.
• W2124672011 hasConcept C555283112 @default.
• W2124672011 hasConcept C71924100 @default.
• W2124672011 hasConcept C81885089 @default.
• W2124672011 hasConcept C86803240 @default.
• W2124672011 hasConceptScore W2124672011C104317684 @default.
• W2124672011 hasConceptScore W2124672011C120599132 @default.
• W2124672011 hasConceptScore W2124672011C126322002 @default.
• W2124672011 hasConceptScore W2124672011C143589142 @default.
• W2124672011 hasConceptScore W2124672011C143998085 @default.
• W2124672011 hasConceptScore W2124672011C180754005 @default.
• W2124672011 hasConceptScore W2124672011C2776715637 @default.
• W2124672011 hasConceptScore W2124672011C2778264664 @default.
• W2124672011 hasConceptScore W2124672011C30481170 @default.
• W2124672011 hasConceptScore W2124672011C36823959 @default.
• W2124672011 hasConceptScore W2124672011C502942594 @default.
• W2124672011 hasConceptScore W2124672011C54355233 @default.
• W2124672011 hasConceptScore W2124672011C555283112 @default.
• W2124672011 hasConceptScore W2124672011C71924100 @default.
• W2124672011 hasConceptScore W2124672011C81885089 @default.
• W2124672011 hasConceptScore W2124672011C86803240 @default.
• W2124672011 hasIssue "1" @default.
• W2124672011 hasLocation W21246720111 @default.
• W2124672011 hasLocation W21246720112 @default.
• W2124672011 hasOpenAccess W2124672011 @default.
• W2124672011 hasPrimaryLocation W21246720111 @default.

• next