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• W2124687307 startingPage "489" @default.
• W2124687307 abstract "Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. MCAF led to peak histamine release within 1 min. 80% of the subjects tested were responsive to MCAF or anti-IgE, while all were responsive to FMLP. The percentage histamine release by MCAF was, however, less than that seen with anti-IgE or FMLP, but this was attributable to a lesser percent release in nonatopic subjects; atopic subjects responded similarly to all three agonists. MCAF was also shown to activate highly purified human basophils more readily than mixed leukocytes, and its activity was inhibited by a polyclonal rabbit antibody. At a suboptimal concentration (2.5 x 10(-9) M), MCAF was unable to prime the basophil to histamine release by other secretagogues. However, interleukin 3 (IL-3) and IL-5 could each prime basophils for MCAF-induced secretion. Therefore, our results suggest that MCAF may be a major contributor to the histamine-releasing activity seen in peripheral blood mononuclear cell supernatants that has been designated histamine releasing factor(s)." @default.
• W2124687307 created "2016-06-24" @default.
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• W2124687307 date "1992-02-01" @default.
• W2124687307 modified "2023-10-18" @default.
• W2124687307 title "Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils." @default.
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• W2124687307 doi "https://doi.org/10.1084/jem.175.2.489" @default.
• W2124687307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119123" @default.
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