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• W2124690596 endingPage "2872" @default.
• W2124690596 startingPage "2869" @default.
• W2124690596 abstract "Genetic bottlenecks are important events in the genetic diversification of organisms and colonization of new ecological niches. Repeated bottlenecking of RNA viruses often leads to fitness losses due to the operation of Muller's ratchet. Herein we use vesicular stomatitis virus to determine the transmission population size which leads to fitness decreases of virus populations. Remarkably, the effective size of a genetic bottleneck associated with fitness loss is greater when the fitness of the parental population increases. For example, for starting virus populations with low fitness, population transfers of five-clone-to-five-clone passages resulted in a fitness increase. However, when a parental population with high fitness was transferred, 30-clone-to-30-clone passages were required simply to maintain fitness values." @default.
• W2124690596 created "2016-06-24" @default.
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• W2124690596 date "1995-05-01" @default.
• W2124690596 modified "2023-10-14" @default.
• W2124690596 title "Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness" @default.
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• W2124690596 doi "https://doi.org/10.1128/jvi.69.5.2869-2872.1995" @default.
• W2124690596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/188983" @default.
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• W2124690596 hasPublicationYear "1995" @default.
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