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• W2124697669 abstract "Objective Institutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency. In addition to osteoporosis-related disorders, vitamin D deficiency may influence several medical conditions conferring an increased mortality risk. The aim of this study was to explore the prevalence of vitamin D deficiency and its association with mortality. Design The Study of Health and Drugs in the Elderly (SHADES) is a prospective cohort study among elderly people (>65 years) in 11 nursing homes in Sweden. Methods We analysed the levels of 25-hydroxyvitamin D 3 (25(OH)D 3 ) at baseline. Vital status of the subjects was ascertained and hazard ratios (HRs) for mortality according to 25(OH)D 3 quartiles were calculated. Results We examined 333 study participants with a mean follow-up of 3 years. A total of 147 (44%) patients died within this period. Compared with the subjects in Q4 (25(OH)D 3 >48 nmol/l), HR (with 95% CI) for mortality was 2.02 (1.31–3.12) in Q1 (25(OH)D 3 <29 nmol/l) ( P <0.05); 2.03 (1.32–3.14) in Q2 (25(OH)D 3 30–37 nmol/l) ( P <0.05) and 1.6 (1.03–2.48) in Q3 (25(OH)D 3 38–47 nmol/l) ( P <0.05). The mean 25(OH)D 3 concentration was 40.2 nmol/l ( s.d . 16.0) and 80% had 25(OH)D 3 below 50 nmol/l. The vitamin D levels decreased from baseline to the second and third measurements. Conclusions Vitamin D deficiency was highly prevalent and associated with increased mortality among the elderly in Swedish nursing homes. Strategies are needed to prevent, and maybe treat, vitamin D deficiency in the elderly in nursing homes and the benefit of vitamin D supplementation should be evaluated in randomised clinical trials." @default.
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• W2124697669 date "2014-05-01" @default.
• W2124697669 modified "2023-10-16" @default.
• W2124697669 title "Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality" @default.
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• W2124697669 doi "https://doi.org/10.1530/eje-13-0855" @default.
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