Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124698558> ?p ?o ?g. }
- W2124698558 endingPage "209" @default.
- W2124698558 startingPage "197" @default.
- W2124698558 abstract "There is considerable evidence that matrix metalloproteinases (MMPs) are up- and/or downregulated in chronic obstructive pulmonary disease (COPD), particularly in emphysema, in which they probably participate in proteolytic attack on the alveolar wall matrix. Recent data suggest that MMPs also have major roles in driving inflammation or shutting it down, as well as modifying the release of fibrogenic growth factors, processes that are important in the genesis of the various lesions of COPD. In cigarette smoke-induced animal models of emphysema, MMP-12 appears to play a consistent and important role, whereas the data for other MMPs are difficult to interpret. In human lungs, evidence for a role for MMPs is more tenuous and there are numerous contradictions in the literature. Little is known about the effects of MMPs in small airway remodelling, smoke-induced pulmonary hypertension and chronic bronchitis, but MMP-12 participates in experimental small airway modelling. To date, the accumulated data suggest that selective inhibition of MMP-12 might be a viable therapy for emphysema and small airway remodelling, but subtle differences in the functions of MMP-12 in animals and humans mandate caution with this approach. Whether inhibition of other MMPs might be useful is unclear." @default.
- W2124698558 created "2016-06-24" @default.
- W2124698558 creator A5009947587 @default.
- W2124698558 creator A5022269910 @default.
- W2124698558 creator A5035835350 @default.
- W2124698558 date "2011-09-15" @default.
- W2124698558 modified "2023-10-12" @default.
- W2124698558 title "Matrix metalloproteinases in COPD" @default.
- W2124698558 cites W115896630 @default.
- W2124698558 cites W1487442055 @default.
- W2124698558 cites W1503156752 @default.
- W2124698558 cites W1525715720 @default.
- W2124698558 cites W1572585032 @default.
- W2124698558 cites W1613133166 @default.
- W2124698558 cites W1662007645 @default.
- W2124698558 cites W1822096040 @default.
- W2124698558 cites W1958515291 @default.
- W2124698558 cites W1964212862 @default.
- W2124698558 cites W1965414352 @default.
- W2124698558 cites W1965751894 @default.
- W2124698558 cites W1967664694 @default.
- W2124698558 cites W1969380462 @default.
- W2124698558 cites W1971328692 @default.
- W2124698558 cites W1974138511 @default.
- W2124698558 cites W1974972632 @default.
- W2124698558 cites W1979558674 @default.
- W2124698558 cites W1979567907 @default.
- W2124698558 cites W1991379662 @default.
- W2124698558 cites W1993005570 @default.
- W2124698558 cites W1994245692 @default.
- W2124698558 cites W1995781080 @default.
- W2124698558 cites W1995871167 @default.
- W2124698558 cites W1996699792 @default.
- W2124698558 cites W2000477668 @default.
- W2124698558 cites W2002257788 @default.
- W2124698558 cites W2002592975 @default.
- W2124698558 cites W2003893081 @default.
- W2124698558 cites W2004556227 @default.
- W2124698558 cites W2006496081 @default.
- W2124698558 cites W2007383329 @default.
- W2124698558 cites W2010507181 @default.
- W2124698558 cites W2011522236 @default.
- W2124698558 cites W2020094665 @default.
- W2124698558 cites W2020863153 @default.
- W2124698558 cites W2026368238 @default.
- W2124698558 cites W2027296100 @default.
- W2124698558 cites W2028166577 @default.
- W2124698558 cites W2029970187 @default.
- W2124698558 cites W2031291407 @default.
- W2124698558 cites W2031654076 @default.
- W2124698558 cites W2033644009 @default.
- W2124698558 cites W2033932219 @default.
- W2124698558 cites W2040099837 @default.
- W2124698558 cites W2040557727 @default.
- W2124698558 cites W204164459 @default.
- W2124698558 cites W2042052594 @default.
- W2124698558 cites W2046676482 @default.
- W2124698558 cites W2049588249 @default.
- W2124698558 cites W2050110637 @default.
- W2124698558 cites W2052543836 @default.
- W2124698558 cites W2052969855 @default.
- W2124698558 cites W2054353564 @default.
- W2124698558 cites W2054435322 @default.
- W2124698558 cites W2060763719 @default.
- W2124698558 cites W2062002285 @default.
- W2124698558 cites W2062604022 @default.
- W2124698558 cites W2065149104 @default.
- W2124698558 cites W2065487751 @default.
- W2124698558 cites W2067827123 @default.
- W2124698558 cites W2072649524 @default.
- W2124698558 cites W207268442 @default.
- W2124698558 cites W2075129895 @default.
- W2124698558 cites W2079515802 @default.
- W2124698558 cites W2079844680 @default.
- W2124698558 cites W2081820280 @default.
- W2124698558 cites W2082723381 @default.
- W2124698558 cites W2082938069 @default.
- W2124698558 cites W2083155349 @default.
- W2124698558 cites W2088945370 @default.
- W2124698558 cites W2090196544 @default.
- W2124698558 cites W2094071833 @default.
- W2124698558 cites W2097292545 @default.
- W2124698558 cites W2099969611 @default.
- W2124698558 cites W2105004180 @default.
- W2124698558 cites W2105216609 @default.
- W2124698558 cites W2105585625 @default.
- W2124698558 cites W2105603763 @default.
- W2124698558 cites W2106629880 @default.
- W2124698558 cites W2107023570 @default.
- W2124698558 cites W2107834294 @default.
- W2124698558 cites W2107994145 @default.
- W2124698558 cites W2109102415 @default.
- W2124698558 cites W2112008499 @default.
- W2124698558 cites W2112652806 @default.
- W2124698558 cites W2113330072 @default.
- W2124698558 cites W2115062467 @default.
- W2124698558 cites W2115244736 @default.
- W2124698558 cites W2119739876 @default.